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Cathepsin 3D structures
From Proteopedia
(Difference between revisions)
(New page: == 3D Structures of Cathepsin == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| * Procathepsin-A (Lysosomal protec...) |
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**[[4cia]], [[4cib]] - hCTSB + inhibitor<br /> | **[[4cia]], [[4cib]] - hCTSB + inhibitor<br /> | ||
| - | * Procathepsin-B | + | *Cathepsin-A |
| + | |||
| + | **[[7kdv]] - hCTSB in Lysosomal Multienzyme Complex – Cryo EM<br /> | ||
| + | |||
| + | * Procathepsin-B or cysteine peptidase | ||
**[[1pbh]], [[2pbh]], [[3pbh]] – hPCTSB <br /> | **[[1pbh]], [[2pbh]], [[3pbh]] – hPCTSB <br /> | ||
**[[1mir]] - rPCTSB (mutant) - rat<br /> | **[[1mir]] - rPCTSB (mutant) - rat<br /> | ||
**[[4n4z]], [[4hwy]] - TbCTSB – ''Trypanosoma brucei''<br /> | **[[4n4z]], [[4hwy]] - TbCTSB – ''Trypanosoma brucei''<br /> | ||
| - | **[[5fpw]] – TbCTSB (mutant)<br /> | + | **[[5fpw]], [[7e3e]], [[7e3f]], [[7e3g]] – TbCTSB (mutant)<br /> |
* Cathepsin-B mature | * Cathepsin-B mature | ||
| Line 39: | Line 43: | ||
**[[1k3b]] – hMCTSC <br /> | **[[1k3b]] – hMCTSC <br /> | ||
**[[2djf]], [[2djg]], [[4oel]], [[4oem]] – hMCTSC + dipeptide<br /> | **[[2djf]], [[2djg]], [[4oel]], [[4oem]] – hMCTSC + dipeptide<br /> | ||
| - | **[[3pdf]], [[4cdc]], [[4cdd]], [[4cde]], [[4cdf]] – hMCTSC + inhibitor<br /> | + | **[[3pdf]], [[4cdc]], [[4cdd]], [[4cde]], [[4cdf]], [[6ic5]], [[6ic6]], [[6ic7]], [[6rn6]], [[6rn7]], [[6rn9]], [[6rni]] – hMCTSC + inhibitor<br /> |
**[[1jqp]] – rMCTSC <br /> | **[[1jqp]] – rMCTSC <br /> | ||
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**[[1lyb]] - hMCTSD+pepstatin<br /> | **[[1lyb]] - hMCTSD+pepstatin<br /> | ||
**[[4obz]], [[4oc6]], [[4od9]] – hMCTSD + non-peptidic inhibitor<br /> | **[[4obz]], [[4oc6]], [[4od9]] – hMCTSD + non-peptidic inhibitor<br /> | ||
| + | **[[6qbg]], [[6qbh]], [[6qcb]] – hMCTSD + macrocyclic inhibitor<br /> | ||
**[[5ux4]] – rMCTSD + inhibitor<br /> | **[[5ux4]] – rMCTSD + inhibitor<br /> | ||
| Line 61: | Line 66: | ||
**[[1kyn]] – hMCTSG +naphthalene inhibitor<br /> | **[[1kyn]] – hMCTSG +naphthalene inhibitor<br /> | ||
**[[1au8]], [[1cgh]] - hMCTSG +phosphonate inhibitor<br /> | **[[1au8]], [[1cgh]] - hMCTSG +phosphonate inhibitor<br /> | ||
| - | **[[1t32]] - hMCTSG +piperidine inhibitor | + | **[[1t32]] - hMCTSG +piperidine inhibitor<br /> |
| + | **[[6vtm]] – hMCTSG + MAP domain-containing protein<br /> | ||
*Procathepsin-H | *Procathepsin-H | ||
| Line 79: | Line 85: | ||
* Cathepsin-K mature | * Cathepsin-K mature | ||
| - | **[[4n79]], [[5tun]], [[4yva]] – hMCTSK<br /> | + | **[[4n79]], [[5tun]], [[4yva]], [[7pck]] – hMCTSK<br /> |
**[[5jh3]], [[5z5o]] – hMCTSK (mutant) <br /> | **[[5jh3]], [[5z5o]] – hMCTSK (mutant) <br /> | ||
**[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]], [[3o0u]] – hMCTSK+ pyrimidine inhibitor<br /> | **[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]], [[3o0u]] – hMCTSK+ pyrimidine inhibitor<br /> | ||
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**[[2aux]], [[2auz]] - hMCTSK + semicarbazone inhibitor<br /> | **[[2aux]], [[2auz]] - hMCTSK + semicarbazone inhibitor<br /> | ||
**[[1ayu]], [[1ayv]], [[1ayw]] - hMCTSK + carbohydrazide inhibitor<br /> | **[[1ayu]], [[1ayv]], [[1ayw]] - hMCTSK + carbohydrazide inhibitor<br /> | ||
| - | **[[2bdl]], [[1yk7]], [[1tu6]], [[1au3]], [[1au4]], [[4dmx]], [[4dmy]] - hMCTSK + pyrrolidine inhibitor<br /> | + | **[[2bdl]], [[1yk7]], [[1tu6]], [[1au3]], [[1au4]], [[4dmx]], [[4dmy]], [[6ql8]] - hMCTSK + pyrrolidine inhibitor<br /> |
**[[1snk]] - hMCTSK + norleucine inhibitor<br /> | **[[1snk]] - hMCTSK + norleucine inhibitor<br /> | ||
**[[1nl6]], [[1nlj]] - hMCTSK+ azepanone inhibitor<br /> | **[[1nl6]], [[1nlj]] - hMCTSK+ azepanone inhibitor<br /> | ||
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**[[1au2]] - hMCTSK+ propanone inhibitor<br /> | **[[1au2]] - hMCTSK+ propanone inhibitor<br /> | ||
**[[1atk]] – hMCTSK+guanidine inhibitor<br /> | **[[1atk]] – hMCTSK+guanidine inhibitor<br /> | ||
| - | **[[1vsn]], [[5j94]], [[4x6h]], [[4x6i]], [[6qbs]] - hMCTSK+ inhibitor<br /> | + | **[[1vsn]], [[5j94]], [[4x6h]], [[4x6i]], [[6qbs]], [[6hgy]], [[6pxf]], [[6qlx]], [[6qm0]], [[7nxl]], [[7qbm]], [[7qbn]], [[7qbo]] - hMCTSK+ inhibitor<br /> |
**[[6ash]] – hMCTSK (mutant) + inhibitor<br /> | **[[6ash]] – hMCTSK (mutant) + inhibitor<br /> | ||
**[[2ato]] – hMCTSK+myocrisin<br /> | **[[2ato]] – hMCTSK+myocrisin<br /> | ||
| - | **[[1u9v]], [[1u9x]], [[1mem]] – hMCTSK+piperazine inhibitor<br /> | + | **[[1u9v]], [[1u9x]], [[1mem]], [[6qlm]], [[6qlw]] – hMCTSK+piperazine inhibitor<br /> |
**[[1u9w]] - hMCTSK+imidazole inhibitor<br /> | **[[1u9w]] - hMCTSK+imidazole inhibitor<br /> | ||
**[[5tdi]], [[4yv8]] – hMCTSK + odanacatib<br /> | **[[5tdi]], [[4yv8]] – hMCTSK + odanacatib<br /> | ||
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**[[4axl]] – hMCTSL1 catalytic domain<br /> | **[[4axl]] – hMCTSL1 catalytic domain<br /> | ||
| - | **[[3iv2]], [[5i4h]] – hMCTSL1 (mutant) <br /> | + | **[[3iv2]], [[5i4h]], [[6jd0]], [[6jd8]] – hMCTSL1 (mutant) <br /> |
**[[3k24]] - hMCTSL1 (mutant) +tripeptide<br /> | **[[3k24]] - hMCTSL1 (mutant) +tripeptide<br /> | ||
**[[3of8]] - hMCTSL1 + dipeptidyl inhibitor<br /> | **[[3of8]] - hMCTSL1 + dipeptidyl inhibitor<br /> | ||
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**[[5qbu]], [[5qbw]], [[5qbx]], [[5qbz]], [[5qc0]], [[5qc1]], [[5qc2]], [[5qc3]], [[5qc5]], [[5qc6]], [[5qc7]], [[5qc8]], [[5qc9]], [[5qca]], [[5qcb]] – hMCTSS (mutant) + piperidine inhibitor<br /> | **[[5qbu]], [[5qbw]], [[5qbx]], [[5qbz]], [[5qc0]], [[5qc1]], [[5qc2]], [[5qc3]], [[5qc5]], [[5qc6]], [[5qc7]], [[5qc8]], [[5qc9]], [[5qca]], [[5qcb]] – hMCTSS (mutant) + piperidine inhibitor<br /> | ||
**[[2op3]], [[2hhn]], [[2g7y]], [[2hh5]], [[2f1g]] – hMCTSS+aryl inhibitor<br /> | **[[2op3]], [[2hhn]], [[2g7y]], [[2hh5]], [[2f1g]] – hMCTSS+aryl inhibitor<br /> | ||
| - | **[[2fud]], [[2fra]], [[2frq]], [[2ft2]], [[1npz]], [[1nqc]], [[4p6e]], [[4p6g]] – hMCTSS+inhibitor<br /> | + | **[[2fud]], [[2fra]], [[2frq]], [[2ft2]], [[1npz]], [[1nqc]], [[4p6e]], [[4p6g]], [[6yyn]], [[6yyo]], [[6yyp]], [[6yyq]], [[6yyr]] – hMCTSS+inhibitor<br /> |
**[[2fye]], [[2g6d]] – hMCTSS (mutant)+inhibitor<br /> | **[[2fye]], [[2g6d]] – hMCTSS (mutant)+inhibitor<br /> | ||
**[[2fq9]], [[1ms6]] – hMCTSS +nitrile inhibitor<br /> | **[[2fq9]], [[1ms6]] – hMCTSS +nitrile inhibitor<br /> | ||
Current revision
3D Structures of Cathepsin
Updated on 15-November-2022
