1g2n

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[[Image:1g2n.gif|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF THE ULTRASPIRACLE PROTEIN USP, THE ORTHOLOG OF RXRS IN INSECTS==
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The line below this paragraph, containing "STRUCTURE_1g2n", creates the "Structure Box" on the page.
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<StructureSection load='1g2n' size='340' side='right'caption='[[1g2n]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1g2n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Heliothis_virescens Heliothis virescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G2N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPH:L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE'>EPH</scene></td></tr>
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{{STRUCTURE_1g2n| PDB=1g2n | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g2n OCA], [https://pdbe.org/1g2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g2n RCSB], [https://www.ebi.ac.uk/pdbsum/1g2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g2n ProSAT]</span></td></tr>
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</table>
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'''CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF THE ULTRASPIRACLE PROTEIN USP, THE ORTHOLOG OF RXRS IN INSECTS'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q7SIF6_HELVI Q7SIF6_HELVI]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The major postembryonic developmental events happening in insect life, including molting and metamorphosis, are regulated and coordinated temporally by pulses of ecdysone. The biological activity of this steroid hormone is mediated by two nuclear receptors: the ecdysone receptor (EcR) and the Ultraspiracle protein (USP). The crystal structure of the ligand-binding domain from the lepidopteran Heliothis virescens USP reported here shows that the loop connecting helices H1 and H3 precludes the canonical agonist conformation. The key residues that stabilize this unique loop conformation are strictly conserved within the lepidopteran USP family. The presence of an unexpected bound ligand that drives an unusual antagonist conformation confirms the induced-fit mechanism accompanying the ligand binding. The ligand-binding pocket exhibits a retinoid X receptor-like anchoring part near a conserved arginine, which could interact with a USP ligand functional group. The structure of this receptor provides the template for designing inhibitors, which could be utilized as a novel type of environmentally safe insecticides.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/1g2n_consurf.spt"</scriptWhenChecked>
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1G2N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Heliothis_virescens Heliothis virescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G2N OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects., Billas IM, Moulinier L, Rochel N, Moras D, J Biol Chem. 2001 Mar 9;276(10):7465-74. Epub 2000 Oct 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11053444 11053444]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g2n ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Heliothis virescens]]
[[Category: Heliothis virescens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Billas, I M.L.]]
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[[Category: Billas IML]]
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[[Category: Moras, D.]]
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[[Category: Moras D]]
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[[Category: Moulinier, L.]]
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[[Category: Moulinier L]]
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[[Category: Rochel, N.]]
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[[Category: Rochel N]]
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[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: Antiparallel alpha-helical sandwich]]
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[[Category: Spine]]
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[[Category: Structural genomic]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:06:36 2008''
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Current revision

CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF THE ULTRASPIRACLE PROTEIN USP, THE ORTHOLOG OF RXRS IN INSECTS

PDB ID 1g2n

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