6jwd
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==structure of RET G-quadruplex in complex with berberine== | |
| + | <StructureSection load='6jwd' size='340' side='right'caption='[[6jwd]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6jwd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JWD FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BER:BERBERINE'>BER</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jwd OCA], [https://pdbe.org/6jwd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jwd RCSB], [https://www.ebi.ac.uk/pdbsum/6jwd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jwd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | G-quadruplexes (G4s) are frequently formed in the promoter regions of oncogenes, considered as promising drug targets for anticancer therapy. Due to high structure similarity of G4s, discovering ligands selectively interacting with only one G4 is extremely difficult. Here, mainly by NMR, we report that colchicine selectively binds to oncogene RET G4-DNA. | ||
| - | + | Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR.,Wang F, Wang C, Liu Y, Lan W, Han H, Wang R, Huang S, Cao C Chem Commun (Camb). 2020 Feb 18;56(14):2099-2102. doi: 10.1039/d0cc00221f. Epub, 2020 Feb 6. PMID:32025680<ref>PMID:32025680</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6jwd" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cao C]] | ||
| + | [[Category: Lan WX]] | ||
| + | [[Category: Li YM]] | ||
| + | [[Category: Liu Y]] | ||
| + | [[Category: Wang C]] | ||
| + | [[Category: Wang F]] | ||
| + | [[Category: Wang RX]] | ||
Current revision
structure of RET G-quadruplex in complex with berberine
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Categories: Homo sapiens | Large Structures | Cao C | Lan WX | Li YM | Liu Y | Wang C | Wang F | Wang RX
