6mxz
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of 53BP1 Tudor domains in complex with small molecule UNC3474== | |
| - | + | <StructureSection load='6mxz' size='340' side='right'caption='[[6mxz]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6mxz]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MXZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K6S:N-[3-(tert-butylamino)propyl]-3-(propan-2-yl)benzamide'>K6S</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mxz OCA], [https://pdbe.org/6mxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mxz RCSB], [https://www.ebi.ac.uk/pdbsum/6mxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mxz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Botuyan MV]] | ||
| + | [[Category: Cui G]] | ||
| + | [[Category: Mer G]] | ||
| + | [[Category: Schuller DJ]] | ||
Current revision
Structure of 53BP1 Tudor domains in complex with small molecule UNC3474
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