6odc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of HDAC8 in complex with compound 30== | |
| + | <StructureSection load='6odc' size='340' side='right'caption='[[6odc]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6odc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ODC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=M7Y:(2E)-3-[2-(3-cyclopentyl-5,5-dimethyl-2-oxoimidazolidin-1-yl)phenyl]-N-hydroxyprop-2-enamide'>M7Y</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6odc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odc OCA], [https://pdbe.org/6odc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6odc RCSB], [https://www.ebi.ac.uk/pdbsum/6odc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6odc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HDAC8_HUMAN HDAC8_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.<ref>PMID:10748112</ref> <ref>PMID:10926844</ref> <ref>PMID:10922473</ref> <ref>PMID:14701748</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | |
| - | + | == References == | |
| - | [[ | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Barczak | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Bair K]] |
| - | [[Category: | + | [[Category: Barczak N]] |
| - | [[Category: | + | [[Category: Caravella J]] |
| - | [[Category: | + | [[Category: Conti C]] |
| - | [[Category: | + | [[Category: Garcia-Dancey R]] |
| - | [[Category: | + | [[Category: Han B]] |
| - | [[Category: | + | [[Category: Hardy C]] |
| - | [[Category: | + | [[Category: Lahdenranta J]] |
| - | [[Category: | + | [[Category: Lancia Jr D]] |
| - | [[Category: Liu | + | [[Category: Leng C]] |
| - | [[Category: | + | [[Category: Li P]] |
| - | [[Category: | + | [[Category: Liu C]] |
| - | [[Category: | + | [[Category: Martin M]] |
| - | [[Category: | + | [[Category: Ng PY]] |
| - | [[Category: Saldahna | + | [[Category: Pardo E]] |
| - | [[Category: | + | [[Category: Rudnitskaya A]] |
| - | [[Category: | + | [[Category: Saldahna A]] |
| - | [[Category: | + | [[Category: Tan T]] |
| - | [[Category: | + | [[Category: Thomason JJ]] |
| - | [[Category: | + | [[Category: Toms AV]] |
| - | [[Category: | + | [[Category: Yao L]] |
| + | [[Category: Zablocki M-M]] | ||
| + | [[Category: Zhang C]] | ||
| + | [[Category: Zheng X]] | ||
Current revision
Crystal structure of HDAC8 in complex with compound 30
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Categories: Homo sapiens | Large Structures | Bair K | Barczak N | Caravella J | Conti C | Garcia-Dancey R | Han B | Hardy C | Lahdenranta J | Lancia Jr D | Leng C | Li P | Liu C | Martin M | Ng PY | Pardo E | Rudnitskaya A | Saldahna A | Tan T | Thomason JJ | Toms AV | Yao L | Zablocki M-M | Zhang C | Zheng X
