6riq
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6riq is ON HOLD until Paper Publication Authors: Szewczak-Harris, A., Wagstaff, J., Lowe, J. Description: MinCD filament from Pseudomonas aeruginos...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==MinCD filament from Pseudomonas aeruginosa== | |
| + | <SX load='6riq' size='340' side='right' viewer='molstar' caption='[[6riq]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6riq]] is a 22 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RIQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6riq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6riq OCA], [https://pdbe.org/6riq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6riq RCSB], [https://www.ebi.ac.uk/pdbsum/6riq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6riq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MINC_PSEAE MINC_PSEAE] Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.[HAMAP-Rule:MF_00267] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Positioning of the division site in many bacterial species relies on the MinCDE system, which prevents the cytokinetic Z-ring from assembling anywhere but the mid-cell, through an oscillatory diffusion-reaction mechanism. MinD dimers bind to membranes and, via their partner MinC, inhibit the polymerization of cell division protein FtsZ into the Z-ring. MinC and MinD form polymeric assemblies in solution and on cell membranes. Here, we report the high-resolution cryo-EM structure of the copolymeric filaments of Pseudomonas aeruginosa MinCD. The filaments consist of three protofilaments made of alternating MinC and MinD dimers. The MinCD protofilaments are almost completely straight and assemble as single protofilaments on lipid membranes, which we also visualized by cryo-EM. | ||
| - | + | Cryo-EM structure of the MinCD copolymeric filament from Pseudomonas aeruginosa at 3.1 A resolution.,Szewczak-Harris A, Wagstaff J, Lowe J FEBS Lett. 2019 Jun 5. doi: 10.1002/1873-3468.13471. PMID:31166018<ref>PMID:31166018</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6riq" style="background-color:#fffaf0;"></div> |
| - | [[Category: Szewczak-Harris | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas aeruginosa]] | ||
| + | [[Category: Lowe J]] | ||
| + | [[Category: Szewczak-Harris A]] | ||
| + | [[Category: Wagstaff J]] | ||
Current revision
MinCD filament from Pseudomonas aeruginosa
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