4r6p

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<StructureSection load='4r6p' size='340' side='right'caption='[[4r6p]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4r6p' size='340' side='right'caption='[[4r6p]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4r6p]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Artocarpus_integer Artocarpus integer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R6P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4r6p]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Artocarpus_integer Artocarpus integer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R6P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=ZZ1:4-METHYL-2H-CHROMEN-2-ONE'>ZZ1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jac|1jac]], [[1ugw|1ugw]], [[1ku8|1ku8]], [[1m26|1m26]], [[1uh0|1uh0]], [[1ugy|1ugy]], [[4r6n|4r6n]], [[4r6o|4r6o]], [[4r6q|4r6q]], [[4r6r|4r6r]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=ZZ1:4-METHYL-2H-CHROMEN-2-ONE'>ZZ1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r6p OCA], [http://pdbe.org/4r6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r6p RCSB], [http://www.ebi.ac.uk/pdbsum/4r6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r6p ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r6p OCA], [https://pdbe.org/4r6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r6p RCSB], [https://www.ebi.ac.uk/pdbsum/4r6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r6p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LECA_ARTIN LECA_ARTIN]] D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum. [[http://www.uniprot.org/uniprot/LECB3_ARTIN LECB3_ARTIN]] D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum.
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[https://www.uniprot.org/uniprot/LECA_ARTIN LECA_ARTIN] D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Artocarpus integer]]
[[Category: Artocarpus integer]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Abhinav, K V]]
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[[Category: Abhinav KV]]
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[[Category: Sharma, K]]
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[[Category: Sharma K]]
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[[Category: Surolia, A]]
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[[Category: Surolia A]]
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[[Category: Swaminathan, C P]]
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[[Category: Swaminathan CP]]
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[[Category: Vijayan, M]]
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[[Category: Vijayan M]]
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[[Category: Beta-prism i fold]]
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[[Category: Galactose]]
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[[Category: Galactose specific lectin]]
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[[Category: Plant lectin]]
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[[Category: Post translational proteolysis]]
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[[Category: Sugar binding protein]]
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[[Category: T-antigen binding protein]]
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Current revision

Jacalin-carbohydrate interactions. Distortion of the ligand as a determinant of affinity.

PDB ID 4r6p

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OCA

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