4r3i

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<StructureSection load='4r3i' size='340' side='right'caption='[[4r3i]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4r3i' size='340' side='right'caption='[[4r3i]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4r3i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R3I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4r3i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R3I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r3h|4r3h]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [https://pdbe.org/4r3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [https://www.ebi.ac.uk/pdbsum/4r3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3i ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YTHDC1, KIAA1966, YT521 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3i OCA], [http://pdbe.org/4r3i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r3i RCSB], [http://www.ebi.ac.uk/pdbsum/4r3i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r3i ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/YTDC1_HUMAN YTDC1_HUMAN]] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:20167602</ref>
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[https://www.uniprot.org/uniprot/YTDC1_HUMAN YTDC1_HUMAN] RNA-binding protein that regulates alternative splice site selection.<ref>PMID:20167602</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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N6-methyladenosine (m6A) is the most abundant internal modification of nearly all eukaryotic mRNAs and has recently been reported to be recognized by the YTH domain family proteins. Here we present the crystal structures of the YTH domain of YTHDC1, a member of the YTH domain family, and its complex with an m6A-containing RNA. Our structural studies, together with transcriptome-wide identification of YTHDC1-binding sites and biochemical experiments, not only reveal the specific mode of m6A-YTH binding but also explain the preferential recognition of the GG(m6A)C sequences by YTHDC1.
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Structural basis for selective binding of mA RNA by the YTHDC1 YTH domain.,Xu C, Wang X, Liu K, Roundtree IA, Tempel W, Li Y, Lu Z, He C, Min J Nat Chem Biol. 2014 Sep 21. doi: 10.1038/nchembio.1654. PMID:25242552<ref>PMID:25242552</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4r3i" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Synthetic construct]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M]]
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[[Category: Bountra C]]
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[[Category: Li, Y]]
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[[Category: Edwards AM]]
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[[Category: Liu, K]]
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[[Category: Li Y]]
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[[Category: Min, J]]
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[[Category: Liu K]]
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[[Category: Structural genomic]]
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[[Category: Min J]]
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[[Category: Tempel, W]]
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[[Category: Tempel W]]
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[[Category: Xu, C]]
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[[Category: Xu C]]
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[[Category: Rna binding protein-rna complex]]
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[[Category: Sgc]]
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Current revision

The crystal structure of an RNA complex

PDB ID 4r3i

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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