|
|
| (One intermediate revision not shown.) |
| Line 3: |
Line 3: |
| | <StructureSection load='4r6u' size='340' side='right'caption='[[4r6u]], [[Resolution|resolution]] 2.80Å' scene=''> | | <StructureSection load='4r6u' size='340' side='right'caption='[[4r6u]], [[Resolution|resolution]] 2.80Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4r6u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R6U FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4r6u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R6U FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL18R1, IL1RRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IL18, IGIF, IL1F4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r6u OCA], [http://pdbe.org/4r6u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r6u RCSB], [http://www.ebi.ac.uk/pdbsum/4r6u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r6u ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r6u OCA], [https://pdbe.org/4r6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r6u RCSB], [https://www.ebi.ac.uk/pdbsum/4r6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r6u ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/IL18R_HUMAN IL18R_HUMAN]] Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B. [[http://www.uniprot.org/uniprot/IL18_HUMAN IL18_HUMAN]] Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. | + | [https://www.uniprot.org/uniprot/IL18R_HUMAN IL18R_HUMAN] Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
| Line 21: |
Line 21: |
| | | | |
| | ==See Also== | | ==See Also== |
| - | *[[Interleukin|Interleukin]] | + | *[[Interleukin 3D structures|Interleukin 3D structures]] |
| - | *[[Interleukin receptor|Interleukin receptor]] | + | *[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Wang, X]] | + | [[Category: Wang X]] |
| - | [[Category: Wei, H]] | + | [[Category: Wei H]] |
| - | [[Category: Beta-trefoil fold]]
| + | |
| - | [[Category: Ig-like fold]]
| + | |
| - | [[Category: Immune system]]
| + | |
| Structural highlights
Function
IL18R_HUMAN Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.
Publication Abstract from PubMed
Interleukin 18 (IL-18), a member of the IL-1 family of cytokines, is an important regulator of innate and acquired immune responses. It signals through its ligand-binding primary receptor IL-18Ralpha and accessory receptor IL-18Rbeta. Here we report the crystal structure of IL-18 with the ectodomain of IL-18Ralpha, which reveals the structural basis for their specific recognition. It confirms that surface charge complementarity determines the ligand-binding specificity of primary receptors in the IL-1 receptor family. We suggest that IL-18 signaling complex adopts an architecture similar to other agonistic cytokines and propose a general ligand-receptor assembly and activation model for the IL-1 family.
Structural basis for the specific recognition of IL-18 by its alpha receptor.,Wei H, Wang D, Qian Y, Liu X, Fan S, Yin HS, Wang X FEBS Lett. 2014 Sep 26. pii: S0014-5793(14)00696-6. doi:, 10.1016/j.febslet.2014.09.019. PMID:25261253[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Wei H, Wang D, Qian Y, Liu X, Fan S, Yin HS, Wang X. Structural basis for the specific recognition of IL-18 by its alpha receptor. FEBS Lett. 2014 Sep 26. pii: S0014-5793(14)00696-6. doi:, 10.1016/j.febslet.2014.09.019. PMID:25261253 doi:http://dx.doi.org/10.1016/j.febslet.2014.09.019
|
