4r5n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:44, 20 September 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='4r5n' size='340' side='right'caption='[[4r5n]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4r5n' size='340' side='right'caption='[[4r5n]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4r5n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R5N FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4r5n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R5N FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3J9:(4R,4AS,10AR)-8-(2-FLUOROPYRIDIN-3-YL)-4A-METHYL-3,4,4A,10A-TETRAHYDRO-2H-SPIRO[1,3-OXAZOLE-4,10-PYRANO[3,2-B]CHROMEN]-2-AMINE'>3J9</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n00|4n00]], [[4rrn|4rrn]], [[4rro|4rro]], [[4rrs|4rrs]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3J9:(4R,4AS,10AR)-8-(2-FLUOROPYRIDIN-3-YL)-4A-METHYL-3,4,4A,10A-TETRAHYDRO-2H-SPIRO[1,3-OXAZOLE-4,10-PYRANO[3,2-B]CHROMEN]-2-AMINE'>3J9</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5n OCA], [https://pdbe.org/4r5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r5n RCSB], [https://www.ebi.ac.uk/pdbsum/4r5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5n ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5n OCA], [http://pdbe.org/4r5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r5n RCSB], [http://www.ebi.ac.uk/pdbsum/4r5n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5n ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
+
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 28: Line 26:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Memapsin 2]]
+
[[Category: Smith D]]
-
[[Category: Smith, D]]
+
[[Category: Vigers GPA]]
-
[[Category: Vigers, G P.A]]
+
-
[[Category: Aspartyl protease]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+

Current revision

8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors

PDB ID 4r5n

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4r5n"
Personal tools