4r5d

<table><tr><td colspan='2'>[[4r5d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R5D FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r58|4r58]], [[4r5c|4r5c]], [[4r6f|4r6f]], [[4r6g|4r6g]], [[4r6j|4r6j]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5d OCA], [http://pdbe.org/4r5d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r5d RCSB], [http://www.ebi.ac.uk/pdbsum/4r5d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5d ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Shape complementarity is an important component of molecular recognition, and the ability to precisely adjust the shape of a binding scaffold to match a target of interest would greatly facilitate the creation of high-affinity protein reagents and therapeutics. Here we describe a general approach to control the shape of the binding surface on repeat-protein scaffolds and apply it to leucine-rich-repeat proteins. First, self-compatible building-block modules are designed that, when polymerized, generate surfaces with unique but constant curvatures. Second, a set of junction modules that connect the different building blocks are designed. Finally, new proteins with custom-designed shapes are generated by appropriately combining building-block and junction modules. Crystal structures of the designs illustrate the power of the approach in controlling repeat-protein curvature.

Control of repeat-protein curvature by computational protein design.,Park K, Shen BW, Parmeggiani F, Huang PS, Stoddard BL, Baker D Nat Struct Mol Biol. 2015 Jan 12. doi: 10.1038/nsmb.2938. PMID:25580576<ref>PMID:25580576</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 4r5d" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Synthetic construct sequences]]

[[Category: Shen, B W]]

[[Category: Stoddard, B L]]

[[Category: De novo protein]]