6ol2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:12, 11 October 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6ol2 is ON HOLD until Paper Publication
+
==Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening==
 +
<StructureSection load='6ol2' size='340' side='right'caption='[[6ol2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[6ol2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OL2 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MU7:N-[2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]-2-iodobenzamide'>MU7</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ol2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ol2 OCA], [https://pdbe.org/6ol2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ol2 RCSB], [https://www.ebi.ac.uk/pdbsum/6ol2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ol2 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/WNK1_RAT WNK1_RAT] Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L.<ref>PMID:17975670</ref> <ref>PMID:20525693</ref>
-
Authors: Chlebowicz, J., Akella, R., Sekulski, K., Humphreys, J.M., Durbacz, M.Z., He, H., Rodan, A., Posner, B., Goldsmith, E.J.
+
==See Also==
-
 
+
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
-
Description: Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
-
[[Category: Goldsmith, E.J]]
+
__TOC__
-
[[Category: Humphreys, J.M]]
+
</StructureSection>
-
[[Category: Chlebowicz, J]]
+
[[Category: Large Structures]]
-
[[Category: Posner, B]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Rodan, A]]
+
[[Category: Akella R]]
-
[[Category: Durbacz, M.Z]]
+
[[Category: Chlebowicz J]]
-
[[Category: Sekulski, K]]
+
[[Category: Durbacz MZ]]
-
[[Category: Akella, R]]
+
[[Category: Goldsmith EJ]]
-
[[Category: He, H]]
+
[[Category: He H]]
 +
[[Category: Humphreys JM]]
 +
[[Category: Posner B]]
 +
[[Category: Rodan A]]
 +
[[Category: Sekulski K]]

Current revision

Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening

PDB ID 6ol2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6ol2"
Personal tools