6oqc
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6oqc is ON HOLD Authors: Huang, X. Description: crystal structure of Mcl1 with inhibitor 9 Category: Unreleased Structures [[Category: Huang, X...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Mcl1 with inhibitor 9== | |
| + | <StructureSection load='6oqc' size='340' side='right'caption='[[6oqc]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6oqc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OQC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N0S:(4S,7aR,9aR,10S,11E,15R)-6-chloro-10-hydroxy-15-methyl-3,4,7a,8,9,9a,10,13,14,15-decahydro-2H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1-naphthalene]-16,16,18(7H,17H)-trione'>N0S</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oqc OCA], [https://pdbe.org/6oqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oqc RCSB], [https://www.ebi.ac.uk/pdbsum/6oqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oqc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Huang | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Huang X]] | ||
Current revision
Crystal structure of Mcl1 with inhibitor 9
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