6oqq
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6oqq is ON HOLD Authors: Tomchick, D.R., Tagliabracci, V.S., Black, M., Osinski, A. Description: Legionella pneumophila SidJ/Saccharomyces cerevisi...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Legionella pneumophila SidJ/Saccharomyces cerevisiae calmodulin complex== | |
| + | <StructureSection load='6oqq' size='340' side='right'caption='[[6oqq]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6oqq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OQQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.102Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oqq OCA], [https://pdbe.org/6oqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oqq RCSB], [https://www.ebi.ac.uk/pdbsum/6oqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oqq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SIDJ_LEGPH SIDJ_LEGPH] Glutamylase that mediates the covalent attachment of glutamate moieties to SdeA on one of the catalytic residues that is required for its mono-ADP-ribosyltransferase activity (PubMed:31330532, PubMed:31330531). In turn, inhibits SdeA ubiquitinating activity. Glutamylates also related SdeB, SdeC and SidE (PubMed:31330531, PubMed:31123136). Glutamylase activity only occurs in the host since it requires host calmodulin (PubMed:28497808, PubMed:31330532, PubMed:31330531, PubMed:31123136). May also reverse the SdeA-mediated substrate ubiquitination by cleaving the phosphodiester bond that links phosphoribosylated ubiquitin to protein substrates via its deubiquitinase activity (PubMed:28497808).<ref>PMID:28497808</ref> <ref>PMID:31123136</ref> <ref>PMID:31330531</ref> <ref>PMID:31330532</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Calmodulin 3D structures|Calmodulin 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Osinski | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Legionella pneumophila]] |
| + | [[Category: Saccharomyces cerevisiae S288C]] | ||
| + | [[Category: Black M]] | ||
| + | [[Category: Osinski A]] | ||
| + | [[Category: Tagliabracci VS]] | ||
| + | [[Category: Tomchick DR]] | ||
Current revision
Legionella pneumophila SidJ/Saccharomyces cerevisiae calmodulin complex
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