6otb
From Proteopedia
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(New page: '''Unreleased structure''' The entry 6otb is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of alpha conotoxin SII== | |
| - | + | <StructureSection load='6otb' size='340' side='right'caption='[[6otb]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6otb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OTB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6otb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6otb OCA], [https://pdbe.org/6otb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6otb RCSB], [https://www.ebi.ac.uk/pdbsum/6otb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6otb ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CAS2_CONST CAS2_CONST] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (PubMed:1390774). This toxin potently inhibits the rodent muscle nAChR (IC(50)=120 nM (adult subtype, alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) and IC(50)=370 nM (fetal subtype, alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND)) and weakly inhibits neuronal nAChRs (PubMed:35357806). In contrast to alpha-conotoxins bearing 2 disulfide bonds (framework I), this conotoxin acts via a unique binding mode with the helix and the N- and C-termini buried in the binding pocket of muscle nAChRs (PubMed:35357806).<ref>PMID:1390774</ref> <ref>PMID:35357806</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Conus striatus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Alewood PF]] | ||
| + | [[Category: Chin YK-Y]] | ||
| + | [[Category: Wilhelm P]] | ||
Current revision
NMR structure of alpha conotoxin SII
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