6r83
From Proteopedia
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==CryoEM structure and molecular model of squid hemocyanin (Todarodes pacificus , TpH)== | ==CryoEM structure and molecular model of squid hemocyanin (Todarodes pacificus , TpH)== | ||
| - | < | + | <SX load='6r83' size='340' side='right' viewer='molstar' caption='[[6r83]], [[Resolution|resolution]] 5.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6r83]] is a 10 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6r83]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Todarodes_pacificus Todarodes pacificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R83 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.1Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r83 OCA], [https://pdbe.org/6r83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r83 RCSB], [https://www.ebi.ac.uk/pdbsum/6r83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r83 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A0P0UX03_TODPA A0A0P0UX03_TODPA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The oxygen transporter of molluscs, hemocyanin, consists of long pearl-necklace-like subunits of several globular domains. The subunits assemble in a complex manner to form cylindrical decamers. Typically, the first six domains of each subunit assemble together to form the cylinder wall, while the C-terminal domains form a collar that fills or caps the cylinder. During evolution, various molluscs have been able to fine-tune their oxygen binding by deleting or adding C-terminal domains and adjusting their inner-collar architecture. However, squids have duplicated one of the wall domains of their subunits instead. Here, using cryo-EM and an optimized refinement protocol implemented in SPHIRE, this work tackled the symmetry-mismatched structure of squid hemocyanin, revealing the precise effect of this duplication on its quaternary structure and providing a potential model for its structural evolution. | ||
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| + | Cryo-EM reveals the asymmetric assembly of squid hemocyanin.,Tanaka Y, Kato S, Stabrin M, Raunser S, Matsui T, Gatsogiannis C IUCrJ. 2019 Apr 5;6(Pt 3):426-437. doi: 10.1107/S205225251900321X. eCollection, 2019 May 1. PMID:31098023<ref>PMID:31098023</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6r83" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Todarodes pacificus]] | [[Category: Todarodes pacificus]] | ||
| - | [[Category: Gatsogiannis | + | [[Category: Gatsogiannis C]] |
| - | [[Category: Kato | + | [[Category: Kato S]] |
| - | [[Category: Matsui | + | [[Category: Matsui T]] |
| - | [[Category: Raunser | + | [[Category: Raunser S]] |
| - | [[Category: Stabrin | + | [[Category: Stabrin M]] |
| - | [[Category: Tanaka | + | [[Category: Tanaka Y]] |
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Current revision
CryoEM structure and molecular model of squid hemocyanin (Todarodes pacificus , TpH)
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