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2uyd

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Current revision (14:57, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2uyd' size='340' side='right'caption='[[2uyd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2uyd' size='340' side='right'caption='[[2uyd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2uyd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus marcescens" (bizio 1823) trevisan in de toni and trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UYD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UYD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2uyd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UYD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1b2v|1b2v]], [[1dk0|1dk0]], [[1dkh|1dkh]], [[1ybj|1ybj]], [[2cn4|2cn4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uyd OCA], [http://pdbe.org/2uyd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uyd RCSB], [http://www.ebi.ac.uk/pdbsum/2uyd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uyd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uyd OCA], [https://pdbe.org/2uyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uyd RCSB], [https://www.ebi.ac.uk/pdbsum/2uyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uyd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HASA_SERMA HASA_SERMA]] Can bind free heme and also acquire it from hemoglobin. Conveys heme from hemoglobin to the HasR receptor which releases it into the bacterium. HasR alone can take up heme but the synergy between HasA and HasR increases heme uptake 100-fold.<ref>PMID:7937909</ref> <ref>PMID:9171402</ref>
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[https://www.uniprot.org/uniprot/HASA_SERMA HASA_SERMA] Can bind free heme and also acquire it from hemoglobin. Conveys heme from hemoglobin to the HasR receptor which releases it into the bacterium. HasR alone can take up heme but the synergy between HasA and HasR increases heme uptake 100-fold.<ref>PMID:7937909</ref> <ref>PMID:9171402</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Caillet-Saguy, C]]
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[[Category: Serratia marcescens]]
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[[Category: Czjzek, M]]
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[[Category: Caillet-Saguy C]]
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[[Category: Fournelle, A]]
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[[Category: Czjzek M]]
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[[Category: Guigliarelli, B]]
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[[Category: Fournelle A]]
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[[Category: Izadi-Pruneyre, N]]
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[[Category: Guigliarelli B]]
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[[Category: Lecroisey, A]]
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[[Category: Izadi-Pruneyre N]]
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[[Category: Heme]]
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[[Category: Lecroisey A]]
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[[Category: Heme acquisition system]]
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[[Category: Heme binding]]
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[[Category: Hemophore]]
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[[Category: Iron]]
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[[Category: Iron ligation]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Metal-binding protein]]
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Current revision

Crystal structure of the SmHasA mutant H83A

PDB ID 2uyd

Drag the structure with the mouse to rotate

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