4ae5

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<StructureSection load='4ae5' size='340' side='right'caption='[[4ae5]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='4ae5' size='340' side='right'caption='[[4ae5]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ae5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AE5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ae5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AE5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ae5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ae5 OCA], [http://pdbe.org/4ae5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ae5 RCSB], [http://www.ebi.ac.uk/pdbsum/4ae5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ae5 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ae5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ae5 OCA], [https://pdbe.org/4ae5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ae5 RCSB], [https://www.ebi.ac.uk/pdbsum/4ae5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ae5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRAP_STAAN TRAP_STAAN]] Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation (By similarity).
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[https://www.uniprot.org/uniprot/TRAP_STAA8 TRAP_STAA8] Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Up-regulates the expression of most toxins and genes known to be necessary for biofilm formation.<ref>PMID:11160124</ref> <ref>PMID:16177293</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Henrick, K]]
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[[Category: Henrick K]]
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[[Category: Hirshberg, M]]
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[[Category: Hirshberg M]]
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[[Category: Biofilm]]
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[[Category: Phosphorylation]]
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[[Category: Quorum sensing]]
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[[Category: Rap]]
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[[Category: Rnaiii]]
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[[Category: Signaling protein]]
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[[Category: Toxin production]]
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Current revision

STRUCTURE OF A MAJOR REGULATOR OF STAPHYLOCOCCAL PATHOGENESIS

PDB ID 4ae5

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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