4twk

From Proteopedia

(Difference between revisions)

Current revision

Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)

Structural highlights

4twk is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.6Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KCNK2_HUMAN Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.^[1] ^[2] ^[3] Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2 (By similarity).^[4] ^[5] ^[6]

References

↑ Meadows HJ, Benham CD, Cairns W, Gloger I, Jennings C, Medhurst AD, Murdock P, Chapman CG. Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. Pflugers Arch. 2000 Apr;439(6):714-22. PMID:10784345
↑ Rinne S, Renigunta V, Schlichthorl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J, Preisig-Muller R. A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels. Pflugers Arch. 2014 Aug;466(8):1559-70. doi: 10.1007/s00424-013-1384-z. Epub 2013, Nov 7. PMID:24196565 doi:http://dx.doi.org/10.1007/s00424-013-1384-z
↑ Bockenhauer D, Zilberberg N, Goldstein SA. KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Nat Neurosci. 2001 May;4(5):486-91. PMID:11319556 doi:http://dx.doi.org/10.1038/87434
↑ Meadows HJ, Benham CD, Cairns W, Gloger I, Jennings C, Medhurst AD, Murdock P, Chapman CG. Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. Pflugers Arch. 2000 Apr;439(6):714-22. PMID:10784345
↑ Rinne S, Renigunta V, Schlichthorl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J, Preisig-Muller R. A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels. Pflugers Arch. 2014 Aug;466(8):1559-70. doi: 10.1007/s00424-013-1384-z. Epub 2013, Nov 7. PMID:24196565 doi:http://dx.doi.org/10.1007/s00424-013-1384-z
↑ Bockenhauer D, Zilberberg N, Goldstein SA. KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Nat Neurosci. 2001 May;4(5):486-91. PMID:11319556 doi:http://dx.doi.org/10.1038/87434

1 Structural highlights
2 Function
3 See Also
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4twk"

@@ Line 3: / Line 3: @@
 <StructureSection load='4twk' size='340' side='right'caption='[[4twk]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4twk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TWK FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4twk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TWK FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=37X:OCTYL+GLUCOSE+NEOPENTYL+GLYCOL'>37X</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCNK2, TREK, TREK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=37X:OCTYL+GLUCOSE+NEOPENTYL+GLYCOL'>37X</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twk OCA], [http://pdbe.org/4twk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4twk RCSB], [http://www.ebi.ac.uk/pdbsum/4twk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4twk ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4twk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twk OCA], [https://pdbe.org/4twk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4twk RCSB], [https://www.ebi.ac.uk/pdbsum/4twk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4twk ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/KCNK2_HUMAN KCNK2_HUMAN]] Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref>   Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2 (By similarity).<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref>
+[https://www.uniprot.org/uniprot/KCNK2_HUMAN KCNK2_HUMAN] Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref>   Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2 (By similarity).<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref>
 ==See Also==
-*[[Potassium Channel|Potassium Channel]]
+*[[Potassium channel 3D structures|Potassium channel 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Ang, J H]]
+[[Category: Ang JH]]
-[[Category: Arrowsmith, C H]]
+[[Category: Arrowsmith CH]]
-[[Category: Berridge, G]]
+[[Category: Berridge G]]
-[[Category: Bountra, C]]
+[[Category: Bountra C]]
-[[Category: Burgess-Brown, N A]]
+[[Category: Burgess-Brown NA]]
-[[Category: Bushell, S R]]
+[[Category: Bushell SR]]
-[[Category: Carpenter, E P]]
+[[Category: Carpenter EP]]
-[[Category: Chalk, R]]
+[[Category: Chalk R]]
-[[Category: Chu, A]]
+[[Category: Chu A]]
-[[Category: Delft, F von]]
+[[Category: Dong L]]
-[[Category: Dong, L]]
+[[Category: Dong YY]]
-[[Category: Dong, Y Y]]
+[[Category: Edwards AM]]
-[[Category: Edwards, A M]]
+[[Category: Faust B]]
-[[Category: Faust, B]]
+[[Category: Goubin S]]
-[[Category: Goubin, S]]
+[[Category: Grieben M]]
-[[Category: Grieben, M]]
+[[Category: Kupinska K]]
-[[Category: Kupinska, K]]
+[[Category: Mackenzie A]]
-[[Category: Mackenzie, A]]
+[[Category: Mukhopadhyay S]]
-[[Category: Mukhopadhyay, S]]
+[[Category: Pike ACW]]
-[[Category: Pike, A C.W]]
+[[Category: Quigley A]]
-[[Category: Quigley, A]]
+[[Category: Shintre CA]]
-[[Category: Shintre, C A]]
+[[Category: Shrestha L]]
-[[Category: Shrestha, L]]
+[[Category: Strain-Damerell C]]
-[[Category: Strain-Damerell, C]]
+[[Category: Tessitore A]]
-[[Category: Tessitore, A]]
+[[Category: Wang D]]
-[[Category: Wang, D]]
+[[Category: Von Delft F]]
-[[Category: Ion channel]]
-[[Category: K2p]]
-[[Category: Membrane protein]]
-[[Category: Transport protein]]

4twk

From Proteopedia

Current revision

Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)

Structural highlights

Function

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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