4u6v

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<StructureSection load='4u6v' size='340' side='right'caption='[[4u6v]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
<StructureSection load='4u6v' size='340' side='right'caption='[[4u6v]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4u6v]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Staah Staah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U6V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U6V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4u6v]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_TCH60 Staphylococcus aureus subsp. aureus TCH60]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U6V FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u6v OCA], [http://pdbe.org/4u6v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u6v RCSB], [http://www.ebi.ac.uk/pdbsum/4u6v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u6v ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u6v OCA], [https://pdbe.org/4u6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u6v RCSB], [https://www.ebi.ac.uk/pdbsum/4u6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u6v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HLA_STAA8 HLA_STAA8]] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity (By similarity).
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[https://www.uniprot.org/uniprot/HLA_STAA8 HLA_STAA8] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Hemolysin|Hemolysin]]
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*[[Hemolysin 3D structures|Hemolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Staah]]
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[[Category: Staphylococcus aureus subsp. aureus TCH60]]
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[[Category: Acqua, W F.Dall]]
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[[Category: Cheng L]]
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[[Category: Cheng, L]]
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[[Category: Dall'Acqua WF]]
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[[Category: Damschroder, M M]]
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[[Category: Damschroder MM]]
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[[Category: Oganesyan, V Y]]
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[[Category: Oganesyan VY]]
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[[Category: Peng, L]]
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[[Category: Peng L]]
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[[Category: Sadowska, A]]
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[[Category: Sadowska A]]
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[[Category: Sellman, B]]
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[[Category: Sellman B]]
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[[Category: Tkaczyk, C]]
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[[Category: Tkaczyk C]]
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[[Category: Wu, H]]
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[[Category: Wu H]]
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[[Category: Alpha toxin]]
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[[Category: Fab]]
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[[Category: Immune system]]
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[[Category: Mutagenesis]]
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[[Category: Staphylococcus aureus]]
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Current revision

Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody

PDB ID 4u6v

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