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1aoj

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THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER

Structural highlights

1aoj is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.5Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

EPS8_MOUSE Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif.

The SH3 domain of Eps8 exists as a novel intertwined dimer.,Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME Nat Struct Biol. 1997 Sep;4(9):739-43. PMID:9303002^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Fazioli F, Minichiello L, Matoska V, Castagnino P, Miki T, Wong WT, Di Fiore PP. Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals. EMBO J. 1993 Oct;12(10):3799-808. PMID:8404850
↑ Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME. The SH3 domain of Eps8 exists as a novel intertwined dimer. Nat Struct Biol. 1997 Sep;4(9):739-43. PMID:9303002

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1aoj"

Categories: Large Structures | Mus musculus | Kishan KVR | Newcomer ME

@@ Line 3: / Line 3: @@
 <StructureSection load='1aoj' size='340' side='right'caption='[[1aoj]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1aoj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AOJ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1aoj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AOJ FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aoj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aoj OCA], [http://pdbe.org/1aoj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1aoj RCSB], [http://www.ebi.ac.uk/pdbsum/1aoj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1aoj ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aoj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aoj OCA], [https://pdbe.org/1aoj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aoj RCSB], [https://www.ebi.ac.uk/pdbsum/1aoj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aoj ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/EPS8_MOUSE EPS8_MOUSE]] Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.<ref>PMID:8404850</ref>
+[https://www.uniprot.org/uniprot/EPS8_MOUSE EPS8_MOUSE] Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.<ref>PMID:8404850</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 27: / Line 28: @@
 </div>
 <div class="pdbe-citations 1aoj" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Epidermal growth factor receptor substrate 3D structures|Epidermal growth factor receptor substrate 3D structures]]
 == References ==
 <references/>
@@ Line 32: / Line 36: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Kishan, K V.R]]
+[[Category: Mus musculus]]
-[[Category: Newcomer, M E]]
+[[Category: Kishan KVR]]
-[[Category: Eps8]]
+[[Category: Newcomer ME]]
-[[Category: Proline rich peptide]]
-[[Category: Sh3 domain]]
-[[Category: Signal transduction]]

1aoj

From Proteopedia

Current revision

THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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