4u4m

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<StructureSection load='4u4m' size='340' side='right'caption='[[4u4m]], [[Resolution|resolution]] 3.09&Aring;' scene=''>
<StructureSection load='4u4m' size='340' side='right'caption='[[4u4m]], [[Resolution|resolution]] 3.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4u4m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U4M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4u4m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U4M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.09&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v8z|2v8z]], [[3n2x|3n2x]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YAGE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4m OCA], [https://pdbe.org/4u4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u4m RCSB], [https://www.ebi.ac.uk/pdbsum/4u4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u4m ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4m OCA], [http://pdbe.org/4u4m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u4m RCSB], [http://www.ebi.ac.uk/pdbsum/4u4m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u4m ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/YAGE_ECOLI YAGE_ECOLI] Catalyzes the formation of 2-keto-3-deoxy-galactonate (KDGal) from pyruvate and glyceraldehyde. Overexpression leads to increased growth (over 2 hours) in the presence of the antibiotics norfloxacin, ampicillin and streptomycin.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bhaskar, V]]
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[[Category: Bhaskar V]]
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[[Category: Krishnaswamy, S]]
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[[Category: Krishnaswamy S]]
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[[Category: Kumar, P Manoj]]
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[[Category: Manicka S]]
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[[Category: Manicka, S]]
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[[Category: Manoj Kumar P]]
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[[Category: Catalytic triad]]
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[[Category: Chemical denaturant]]
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[[Category: Kdga]]
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[[Category: Nal superfamily]]
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[[Category: Schiff base]]
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[[Category: Sugar binding protein]]
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[[Category: Tim barrel]]
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[[Category: Urea promoted unfolding]]
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Current revision

Crystal structure of 0.5M urea unfolded YagE, a KDG aldolase protein in complex with Pyruvate

PDB ID 4u4m

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