Clathrin
From Proteopedia
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<StructureSection load='3lvg' size='350' side='right' caption='Bovine clathrin heavy (darkmagenta, magenta, violet) and light (yellow, green, cyan) chains (PDB entry [[3lvg]])' scene='46/465441/Cv/1'> | <StructureSection load='3lvg' size='350' side='right' caption='Bovine clathrin heavy (darkmagenta, magenta, violet) and light (yellow, green, cyan) chains (PDB entry [[3lvg]])' scene='46/465441/Cv/1'> | ||
| - | '''Clathrin''' (CLT) is a component of vesicle | + | '''Clathrin''' (CLT) is a component of vesicle coats.<ref>PMID:1063406</ref> For details see [[Clathrin JMU]]. |
== Structural highlights == | == Structural highlights == | ||
Clathrin is composed of <scene name='46/465441/Cv/2'>3 heavy chains (Hc) and 3 light chains (Lc) interacting in their C-termini and forming a triskelion</scene>. <ref>PMID:20493816</ref> The Hc domains are: N-terminal, ankle, distal leg, knee, proximal leg and trimerization. | Clathrin is composed of <scene name='46/465441/Cv/2'>3 heavy chains (Hc) and 3 light chains (Lc) interacting in their C-termini and forming a triskelion</scene>. <ref>PMID:20493816</ref> The Hc domains are: N-terminal, ankle, distal leg, knee, proximal leg and trimerization. | ||
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| + | [[FirstGlance/Virus_Capsids_and_Other_Large_Assemblies#Clathrin_Coat|Clathrin Coat]] shows a small, empty clathrin coat assembly of triskelions from an electron microscopic structure, [[3iyv]]. | ||
== 3D Structures of Clathrin == | == 3D Structures of Clathrin == | ||
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of Clathrin == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *clathrin | ||
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| - | **[[1bpo]] – rCLT Hc N terminal domain + linker – rat<br /> | ||
| - | **[[1b89]] – bCLT Hc proximal leg – bovine<br /> | ||
| - | **[[3qil]] - bCLT Hc trimerization domain<br /> | ||
| - | **[[3lvg]] - bCLT Hc + Lc<br /> | ||
| - | **[[3lvh]] - bCLT Hc HUB fragment + Lc <br /> | ||
| - | **[[1xi4]], [[3iyv]] – bCLT Hc + Lc – Cryo EM | ||
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| - | *Clathrin binary complexes | ||
| - | **[[2xzg]], [[4g55]]- hCLT Hc N terminal + pitstop inhibitor - human<br /> | ||
| - | **[[6e4l]] – hCLT Hc N terminal + inhibitor<br /> | ||
| - | **[[1c9i]], [[1c9l]] - rCLT Hc N terminal + B-adaptin 3<br /> | ||
| - | **[[5ods]] – CLT Hcl + phosphoprotein peptide - mouse<br /> | ||
| - | **[[1utc]], [[5m61]], [[5m5t]], [[5m5s]] - bCLT Hc N terminal + amphiphysin peptide<br /> | ||
| - | **[[5m5v]], [[5m5u]] – bCLT Hc N terminal + large delta antigen peptide<br /> | ||
| - | **[[5m5r]] – bCLT Hc N terminal + adaptin peptide<br /> | ||
| - | **[[1xi5]] - bCLT Hc + auxilin J-domain – Cryo EM<br /> | ||
| - | **[[3gc3]] – bCLT Hc WD domain + b-arrestin-1<br /> | ||
| - | **[[3gd1]] - bCLT Hc + Hc WD domain + b-arrest | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Pearse BM. Clathrin: a unique protein associated with intracellular transfer of membrane by coated vesicles. Proc Natl Acad Sci U S A. 1976 Apr;73(4):1255-9. PMID:1063406
- ↑ Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM. Conformation switching of clathrin light chain regulates clathrin lattice assembly. Dev Cell. 2010 May 18;18(5):841-8. PMID:20493816 doi:10.1016/j.devcel.2010.04.007
