Circadian clock protein
From Proteopedia
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<StructureSection load='' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'> | <StructureSection load='' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'> | ||
| - | '''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then '''KaiC''' binds to '''KaiB'''<ref>PMID:15716247</ref> which inactivates '''KaiA''' and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]]. | + | '''Circadian clock proteins''' or '''Circadian clock protein kinase''' measure out the 24 hour circadian rhythm. In cyanobacteria protein '''KaiA'''<ref>PMID:15007067</ref> stimulates '''KaiC'''<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then '''KaiC''' binds to '''KaiB'''<ref>PMID:15716247</ref> which inactivates '''KaiA''' and causes the number of phosphate groups on '''KaiC''' to drop slowly. '''KaiB''' disconnects allowing '''KaiA''' to start the cycle again.<ref>PMID:11687489</ref> For details of '''KaiC''' see [[Circadian Clock Protein KaiC]]. |
Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]). | Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]). | ||
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of circadian clock protein == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *KaiA | ||
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| - | **[[1r5q]] – NoKaiA - Nostoc<br /> | ||
| - | **[[1m2e]], [[1m2f]] – SeKaiA N terminal – ''Synechococcus elongatus'' - NMR <br /> | ||
| - | **[[1q6a]], [[1q6b]] – SeKaiA C terminal - NMR <br /> | ||
| - | **[[1v2z]] – SeKaiA C terminal <br /> | ||
| - | **[[1r8j]] – SeKaiA <br /> | ||
| - | **[[4g86]] – SeKaiA + DBMIB<br /> | ||
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| - | *KaiB | ||
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| - | **[[1r5p]] – NoKaiB <br /> | ||
| - | **[[1wwj]] – SyKaiB - ''Synechocystis''<br /> | ||
| - | **[[1vgl]], [[2qke]], [[4kso]] – SeKaiB <br /> | ||
| - | **[[5jyt]] – SeKaiB (mutant) - NMR <br /> | ||
| - | **[[5jyv]] – SeKaiB (mutant) + CIKA - NMR <br /> | ||
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| - | *KaiC | ||
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| - | **[[1tf7]], [[2gbl]] – SyKaiC <br /> | ||
| - | **[[1u9i]], [[3dvl]], [[3jzm]], [[3s1a]], [[4dug]], [[4ijm]], [[4o0m]] – SeKaiC (mutant) <br /> | ||
| - | **[[4tl8]], [[4tl7]], [[4tl6]], [[5yz8]] – SeKaiC N terminal C1 domain<br /> | ||
| - | **[[4tl9]], [[4tla]], [[4tlb]], [[4tlc]], [[4tld]], [[4tle]], [[3k09]], [[3k0a]], [[3k0c]], [[3k0e]], [[3k0f]] – SeKaiC N terminal C1 domain (mutant)<br /> | ||
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| - | *KaiA+KaiC | ||
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| - | **[[1suy]], [[1sv1]] – SeKaiA C terminal + KaiC peptide - NMR <br /> | ||
| - | **[[5c5e]] – SeKaiA + KaiC peptide <br /> | ||
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| - | *KaiB+KaiC | ||
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| - | **[[5jwo]], [[5jwq]] – SeKaiB (mutant) + KaiC (mutant) <br /> | ||
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| - | *KaiA+KaiB+KaiC | ||
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| - | **[[5n8y]] – SeKaiA + SeKaiB + KaiC – Cryo EM <br /> | ||
| - | **[[5jwr]] – SeKaiA (mutant) + SeKaiB (mutant) + KaiC (mutant) <br /> | ||
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| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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References
- ↑ Ye S, Vakonakis I, Ioerger TR, LiWang AC, Sacchettini JC. Crystal structure of circadian clock protein KaiA from Synechococcus elongatus. J Biol Chem. 2004 May 7;279(19):20511-8. Epub 2004 Mar 8. PMID:15007067 doi:10.1074/jbc.M400077200
- ↑ Pattanayek R, Wang J, Mori T, Xu Y, Johnson CH, Egli M. Visualizing a circadian clock protein: crystal structure of KaiC and functional insights. Mol Cell. 2004 Aug 13;15(3):375-88. PMID:15304218 doi:10.1016/j.molcel.2004.07.013
- ↑ . PMID:15716247
- ↑ Harmer SL, Panda S, Kay SA. Molecular bases of circadian rhythms. Annu Rev Cell Dev Biol. 2001;17:215-53. PMID:11687489 doi:http://dx.doi.org/10.1146/annurev.cellbio.17.1.215
