Hemagglutinin-esterase

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== Structural highlights ==
== Structural highlights ==
The biological assmebly of HE is a <scene name='48/484851/Cv/7'>dimer</scene> and each monomer contains <scene name='48/484851/Cv/8'>3 domains: the membrane fusion domain, the esterase domain and the receptor-binding domain</scene>. The receptor binding site of HE is located at five exposed surface loops. <scene name='48/484851/Cv/9'>Acetylated sialic acid binding site</scene>. HE contains a <scene name='48/484851/Cv/10'>conserved metal-binding site</scene><ref>PMID:22291594</ref>.
The biological assmebly of HE is a <scene name='48/484851/Cv/7'>dimer</scene> and each monomer contains <scene name='48/484851/Cv/8'>3 domains: the membrane fusion domain, the esterase domain and the receptor-binding domain</scene>. The receptor binding site of HE is located at five exposed surface loops. <scene name='48/484851/Cv/9'>Acetylated sialic acid binding site</scene>. HE contains a <scene name='48/484851/Cv/10'>conserved metal-binding site</scene><ref>PMID:22291594</ref>.
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</StructureSection>
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==3D structures of hemagglutinin-esterase==
==3D structures of hemagglutinin-esterase==
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[[Hemagglutinin-esterase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Hemagglutinin-esterase
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**[[3cl4]] – bcvHE – bovine corona virus<br />
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**[[3i1k]] – PtHE (mutant) – porcine torovirus<br />
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**[[3i26]] – BtHE – bovine torovirus<br />
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**[[4c7l]] – mhvHE (mutant) – murine hepatitis virus<br />
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**[[5t9y]] – savHE – salmon anemia virus<br />
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**[[5n11]] – HE – human corona virus<br />
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**[[5jif]] – HE – murine corona virus<br />
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**[[4zxn]] – rcvHE (mutant) – rat coronavirus<br />
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**[[5e64]] – IdvHE – Influenza D virus<br />
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**[[5e5w]] – IdvHE (mutant) <br />
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*Hemagglutinin-esterase complex
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**[[3cl5]] – bcvHE (mutant) + receptor<br />
 
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**[[3i1l]] – PtHE (mutant) + receptor<br />
 
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**[[3i27]] – BtHE + receptor<br />
 
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**[[4c7w]] – mhvHE (mutant) + receptor<br />
 
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**[[5t9y]] – savHE – salmon anemia virus<br />
 
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**[[5jil]] – rcvHE (mutant) + sialic acid derivative <br />
 
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**[[5e62]] – IdvHE + glucopyranoside derivative<br />
 
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**[[5e66]] – IdvHE + receptor analog<br />
 
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**[[5e65]] – IdvHE (mutant) + receptor analog<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Pig torovirus glycosylated hemagglutinin-esterase glycoprotein complex with receptor and acetate 3i1l

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References

  1. ↑ de Groot RJ. Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses. Glycoconj J. 2006 Feb;23(1-2):59-72. PMID:16575523 doi:http://dx.doi.org/10.1007/s10719-006-5438-8
  2. ↑ Langereis MA, Zeng Q, Heesters BA, Huizinga EG, de Groot RJ. The murine coronavirus hemagglutinin-esterase receptor-binding site: a major shift in ligand specificity through modest changes in architecture. PLoS Pathog. 2012 Jan;8(1):e1002492. doi: 10.1371/journal.ppat.1002492. Epub 2012, Jan 26. PMID:22291594 doi:http://dx.doi.org/10.1371/journal.ppat.1002492

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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