Homocitrate synthase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The HS <scene name='46/465446/Cv/7'>active site is located in the interior of the N-terminal TIM-barrel domain</scene>. <scene name='46/465446/Cv/8'>Active site</scene>. The <scene name='46/465446/Cv/9'>metal ion is octahedrally coordinated to the protein and to the 2-oxoglutarate</scene><ref>PMID:19776021</ref>. Water molecules shown as red spheres. | + | The HS <scene name='46/465446/Cv/7'>active site is located in the interior of the N-terminal TIM-barrel domain</scene>. |
| + | *<scene name='46/465446/Cv/8'>Active site</scene>. | ||
| + | *The <scene name='46/465446/Cv/9'>metal ion is octahedrally coordinated to the protein and to the 2-oxoglutarate</scene><ref>PMID:19776021</ref>. Water molecules shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of homocitrate synthase == | == 3D Structures of homocitrate synthase == | ||
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[[2zyf]] - TtHS + α-ketoglutarate + Mg<br /> | [[2zyf]] - TtHS + α-ketoglutarate + Mg<br /> | ||
[[2ztk]] – TtHS + homocitrate<br /> | [[2ztk]] – TtHS + homocitrate<br /> | ||
| - | [[3a9i]] – TtHS + lysine | + | [[3a9i]] – TtHS + lysine<br /> |
| + | [[6ktq]] - HS + -ketoglutarate + CoA – ''Sulfolobus acidocaldarius''<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of homocitrate synthase
Updated on 27-September-2021
3ivs – fyHS Lys4 – fission yeast
3ivt, 3ivu - fyHS Lys4 + 2-oxoglutarate
3mi3 - fyHS Lys4 + lysine
2ztj – TtHS + α-ketoglutarate – Thermus thermophilus
2zyf - TtHS + α-ketoglutarate + Mg
2ztk – TtHS + homocitrate
3a9i – TtHS + lysine
6ktq - HS + -ketoglutarate + CoA – Sulfolobus acidocaldarius
References
- ↑ Strassman M, Ceci LN. Enzymatic formation of homocitric acid, an intermediate in lysine biosynthesis. Biochem Biophys Res Commun. 1964;14:262-7. PMID:5836514
- ↑ Bulfer SL, Scott EM, Couture JF, Pillus L, Trievel RC. Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis. J Biol Chem. 2009 Dec 18;284(51):35769-80. Epub . PMID:19776021 doi:10.1074/jbc.M109.046821
