Journal:Acta Cryst F:S2053230X19007192
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| - | - | + | <StructureSection load='' size='450' side='right' scene='81/815962/Cv/5' caption=''> |
| + | ===Crystal Structure of Flavin Dependent Thymidylate Synthase, Thy1, from ''Thermus thermophilus'' having an Extra C Terminal Domain=== | ||
| + | <big>A. Ogawa, G. Sampei and G. Kawai</big> <ref>doi 10.1107/S2053230X19007192</ref> | ||
| + | <hr/> | ||
| + | <b>Molecular Tour</b><br> | ||
| + | Thy1 is an enzyme which catalyze the reaction to produce thymidine monophosphate from deoxyuridine monophosphate. The Thy1 from ''Thermus thermophilus'' was found , ''Tt''Thy1, have an extra domain with 48 amino acids at the C terminal. BLAST search showed that the CTD domain exists only for Thy1 from Thermus, Marinithermus, Oceanithermus and Truepera. The structure of ''Tt''Thy1 was determined by X-ray crystallography. <scene name='81/815962/Cv/4'>Overall structure</scene> is similar to the known structures and the <scene name='81/815962/Cv/6'>CTD was found to consist of 3 alpha-helices and a beta-strand</scene> ({{Template:ColorKey_Helix}}, | ||
| + | {{Template:ColorKey_Strand}}, | ||
| + | {{Template:ColorKey_Loop}}, | ||
| + | {{Template:ColorKey_Turn}}). <scene name='81/815962/Cv/9'>Structure of CTD</scene>. Conserved residues are in red. | ||
| + | |||
| + | <b>References</b><br> | ||
| + | <references/> | ||
| + | </StructureSection> | ||
| + | __NOEDITSECTION__ | ||
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