6k0c
From Proteopedia
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(New page: '''Unreleased structure''' The entry 6k0c is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of ceNAP1-H2A.Z-H2B complex== | |
| + | <StructureSection load='6k0c' size='340' side='right'caption='[[6k0c]], [[Resolution|resolution]] 2.28Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6k0c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K0C FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.281Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k0c OCA], [https://pdbe.org/6k0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k0c RCSB], [https://www.ebi.ac.uk/pdbsum/6k0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k0c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/H2AV_CAEEL H2AV_CAEEL] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the repression of transcription factor ceh-22 (PubMed:24346701).[UniProtKB:P27661]<ref>PMID:24346701</ref> [https://www.uniprot.org/uniprot/H2B2_CAEEL H2B2_CAEEL] | ||
| - | + | ==See Also== | |
| - | + | *[[Histone 3D structures|Histone 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Caenorhabditis elegans]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Liu YR]] | ||
Current revision
Crystal structure of ceNAP1-H2A.Z-H2B complex
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