4u9l

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Structure of a membrane protein

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Retrieved from "http://52.214.119.220/wiki/index.php/4u9l"

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 <StructureSection load='4u9l' size='340' side='right'caption='[[4u9l]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4u9l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U9L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U9L FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4u9l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U9L FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4u9n|4u9n]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TTHA1060 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u9l OCA], [https://pdbe.org/4u9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u9l RCSB], [https://www.ebi.ac.uk/pdbsum/4u9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u9l ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u9l OCA], [http://pdbe.org/4u9l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u9l RCSB], [http://www.ebi.ac.uk/pdbsum/4u9l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u9l ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/MGTE_THET8 MGTE_THET8]] Acts as a highly selective magnesium channel.<ref>PMID:17700703</ref> <ref>PMID:19798051</ref>
+[https://www.uniprot.org/uniprot/MGTE_THET8 MGTE_THET8] Acts as a highly selective magnesium channel.<ref>PMID:17700703</ref> <ref>PMID:19798051</ref>
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-Magnesium is the most abundant divalent cation in living cells and is crucial to several biological processes. MgtE is a Mg(2+) channel distributed in all domains of life that contributes to the maintenance of cellular Mg(2+) homeostasis. Here we report the high-resolution crystal structures of the transmembrane domain of MgtE, bound to Mg(2+), Mn(2+) and Ca(2+). The high-resolution Mg(2+)-bound crystal structure clearly visualized the hydrated Mg(2+) ion within its selectivity filter. Based on those structures and biochemical analyses, we propose a cation selectivity mechanism for MgtE in which the geometry of the hydration shell of the fully hydrated Mg(2+) ion is recognized by the side-chain carboxylate groups in the selectivity filter. This is in contrast to the K(+)-selective filter of KcsA, which recognizes a dehydrated K(+) ion. Our results further revealed a cation-binding site on the periplasmic side, which regulate channel opening and prevents conduction of near-cognate cations.
-Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg(2+) channel MgtE.,Takeda H, Hattori M, Nishizawa T, Yamashita K, Shah ST, Caffrey M, Maturana AD, Ishitani R, Nureki O Nat Commun. 2014 Nov 4;5:5374. doi: 10.1038/ncomms6374. PMID:25367295<ref>PMID:25367295</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 4u9l" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
@@ Line 25: / Line 15: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Thet8]]
+[[Category: Thermus thermophilus HB8]]
-[[Category: Caffrey, M]]
+[[Category: Caffrey M]]
-[[Category: Hattori, M]]
+[[Category: Hattori M]]
-[[Category: Ishitani, R]]
+[[Category: Ishitani R]]
-[[Category: Maturana, A D]]
+[[Category: Maturana AD]]
-[[Category: Nishizawa, T]]
+[[Category: Nishizawa T]]
-[[Category: Nureki, O]]
+[[Category: Nureki O]]
-[[Category: Shah, S T.A]]
+[[Category: Shah STA]]
-[[Category: Takeda, H]]
+[[Category: Takeda H]]
-[[Category: Yamashita, K]]
+[[Category: Yamashita K]]
-[[Category: Channel]]
-[[Category: Magnesium]]
-[[Category: Metal transport]]

4u9l

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Structure of a membrane protein

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