Cyclin-dependent kinase regulatory subunit
From Proteopedia
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== Function == | == Function == | ||
| - | '''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in <scene name='71/715441/Pdb4yc6/1'>pdb 4yc6</scene> where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red. CKS1 is essential for CDK5 functioning in neuronal differentiation.<ref>PMID:8491379</ref> | + | '''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in <scene name='71/715441/Pdb4yc6/1'>pdb 4yc6</scene> where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red. |
| + | *'''CKS1''' is essential for CDK5 functioning in neuronal differentiation.<ref>PMID:8491379</ref> | ||
| + | *'''CKS2''' is implicated as an oncogene in various malignancies.<ref>PMID:31781310</ref> | ||
== Structural highlights == | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of cyclin-dependent kinase regulatory subunit == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *CKS 1 | ||
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| - | **[[1dks]], [[1dkt]] – hCKS 1 - human<br /> | ||
| - | **[[4lpa]], [[1qb3]] – yCKS 1 - yeast<br /> | ||
| - | **[[3qy2]] – yCKS 1 (mutant)<br /> | ||
| - | **[[1puc]], [[1sce]] – fyCKS 1 – fission yeast<br /> | ||
| - | **[[1cks]] – hCKS 2<br /> | ||
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| - | *CKS 1 complexes | ||
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| - | **[[4yc6]] – hCKS 1 + CDK1 <br /> | ||
| - | **[[1buh]] – hCKS 1 + CDK2<br /> | ||
| - | **[[1h4l]], [[1ung]] – hCKS 1 + CDK5<br /> | ||
| - | **[[1unh]], [[1unl]] – hCKS 1 + CDK5 + inhibitor<br /> | ||
| - | **[[3o0g]] – hCKS 1 + CDK5 + ATP analog<br /> | ||
| - | **[[2ass]] – hCKS 1 + Skp1 + Skp2<br /> | ||
| - | **[[2ast]] – hCKS 1 + Skp1 + Skp2 + CDK inhibitor peptide<br /> | ||
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| - | *CKS 2 | ||
| - | **[[1cks]] – hCKS 2<br /> | ||
| - | **[[4y72]], [[4yc3]], [[5hq0]], [[5lqf]] – hCKS 2 + CDK1 + cyclin B1<br /> | ||
| - | **[[6gu2]] – hCKS 2 + CDK1 + cyclin B + flavopiridol<br /> | ||
| - | **[[6gu7]] – hCKS 2 + CDK1 + inhibitor<br /> | ||
| - | **[[6gu6]] – hCKS 2 + CDK1 + dinaciclib<br /> | ||
| - | **[[6gu3]], [[6gu4]] – hCKS 2 + CDK1 + cyclin B + inhibitor<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Tang Y, Reed SI. The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae. Genes Dev. 1993 May;7(5):822-32. PMID:8491379
- ↑ Zhang J, Song Q, Liu J, Lu L, Xu Y, Zheng W. Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma. Dis Markers. 2019 Oct 22;2019:8964015. PMID:31781310 doi:10.1155/2019/8964015
