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1b66

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<StructureSection load='1b66' size='340' side='right'caption='[[1b66]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1b66' size='340' side='right'caption='[[1b66]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1b66]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B66 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1b66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B66 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BIO:BIOPTERIN'>BIO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-pyruvoyltetrahydropterin_synthase 6-pyruvoyltetrahydropterin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.12 4.2.3.12] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BIO:BIOPTERIN'>BIO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b66 OCA], [http://pdbe.org/1b66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b66 RCSB], [http://www.ebi.ac.uk/pdbsum/1b66 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1b66 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b66 OCA], [https://pdbe.org/1b66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b66 RCSB], [https://www.ebi.ac.uk/pdbsum/1b66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b66 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/PTPS_RAT PTPS_RAT]] Note=Deficiency leads to phenylketonuria.
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[https://www.uniprot.org/uniprot/PTPS_RAT PTPS_RAT] Note=Deficiency leads to phenylketonuria.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTPS_RAT PTPS_RAT]] Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
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[https://www.uniprot.org/uniprot/PTPS_RAT PTPS_RAT] Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 6-pyruvoyltetrahydropterin synthase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Auerbach, G]]
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[[Category: Rattus rattus]]
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[[Category: Huber, R]]
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[[Category: Auerbach G]]
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[[Category: Lee, S]]
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[[Category: Huber R]]
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[[Category: Leimbacher, W]]
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[[Category: Lee S]]
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[[Category: Nar, H]]
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[[Category: Leimbacher W]]
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[[Category: Ploom, T]]
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[[Category: Nar H]]
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[[Category: Richardson, J]]
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[[Category: Ploom T]]
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[[Category: Thoeny, B]]
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[[Category: Richardson J]]
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[[Category: Yim, J]]
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[[Category: Thoeny B]]
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[[Category: Phosphate elimination]]
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[[Category: Yim J]]
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[[Category: Pterine synthesis]]
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[[Category: Tetrahydrobiopterin biosynthesis]]
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Current revision

6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE

PDB ID 1b66

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