6jzc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural basis of tubulin detyrosination== | |
| + | <StructureSection load='6jzc' size='340' side='right'caption='[[6jzc]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6jzc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JZC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.201Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jzc OCA], [https://pdbe.org/6jzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jzc RCSB], [https://www.ebi.ac.uk/pdbsum/6jzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jzc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VASH2_MOUSE VASH2_MOUSE] Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146868). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325).<ref>PMID:19204325</ref> <ref>PMID:29146868</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Chen Z]] | ||
| + | [[Category: Ling Y]] | ||
| + | [[Category: Zeyuan G]] | ||
| + | [[Category: Zhu L]] | ||
Current revision
Structural basis of tubulin detyrosination
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Categories: Homo sapiens | Large Structures | Mus musculus | Chen Z | Ling Y | Zeyuan G | Zhu L
