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6nyy

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==human m-AAA protease AFG3L2, substrate-bound==
==human m-AAA protease AFG3L2, substrate-bound==
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<StructureSection load='6nyy' size='340' side='right'caption='[[6nyy]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<SX load='6nyy' size='340' side='right' viewer='molstar' caption='[[6nyy]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6nyy]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NYY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6nyy]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NYY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nyy OCA], [http://pdbe.org/6nyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nyy RCSB], [http://www.ebi.ac.uk/pdbsum/6nyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nyy ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nyy OCA], [https://pdbe.org/6nyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nyy RCSB], [https://www.ebi.ac.uk/pdbsum/6nyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nyy ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/AFG32_HUMAN AFG32_HUMAN]] Spinocerebellar ataxia type 28;Early-onset spastic ataxia-neuropathy syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/AFG32_HUMAN AFG32_HUMAN] Spinocerebellar ataxia type 28;Early-onset spastic ataxia-neuropathy syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AFG32_HUMAN AFG32_HUMAN]] ATP-dependent protease which is essential for axonal development (By similarity).
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[https://www.uniprot.org/uniprot/AFG32_HUMAN AFG32_HUMAN] ATP-dependent protease which is essential for axonal development (By similarity).
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lander, G C]]
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[[Category: Lander GC]]
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[[Category: Puchades, C]]
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[[Category: Puchades C]]
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[[Category: Aaa+]]
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[[Category: Afg3l2]]
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[[Category: Atpase]]
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[[Category: Inner membrane]]
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[[Category: M/aaa protease]]
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[[Category: Mitochondria]]
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[[Category: Neurodegeneration]]
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[[Category: Protease]]
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[[Category: Protein quality control]]
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[[Category: Translocase]]
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Current revision

human m-AAA protease AFG3L2, substrate-bound

6nyy, resolution 3.00Å

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