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1ohl

From Proteopedia

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<StructureSection load='1ohl' size='340' side='right'caption='[[1ohl]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='1ohl' size='340' side='right'caption='[[1ohl]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ohl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OHL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ohl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OHL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PBG:3-[5-(AMINOMETHYL)-4-(CARBOXYMETHYL)-1H-PYRROL-3-YL]PROPANOIC+ACID'>PBG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aw5|1aw5]], [[1eb3|1eb3]], [[1gjp|1gjp]], [[1h7n|1h7n]], [[1h7o|1h7o]], [[1h7p|1h7p]], [[1h7r|1h7r]], [[1qml|1qml]], [[1qnv|1qnv]], [[1ylv|1ylv]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PBG:3-[5-(AMINOMETHYL)-4-(CARBOXYMETHYL)-1H-PYRROL-3-YL]PROPANOIC+ACID'>PBG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ohl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ohl OCA], [https://pdbe.org/1ohl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ohl RCSB], [https://www.ebi.ac.uk/pdbsum/1ohl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ohl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ohl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ohl OCA], [http://pdbe.org/1ohl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ohl RCSB], [http://www.ebi.ac.uk/pdbsum/1ohl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ohl ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HEM2_YEAST HEM2_YEAST]] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
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[https://www.uniprot.org/uniprot/HEM2_YEAST HEM2_YEAST] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 18824]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Porphobilinogen synthase]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Brindley, A A]]
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[[Category: Brindley AA]]
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[[Category: Butler, D]]
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[[Category: Butler D]]
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[[Category: Coates, L]]
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[[Category: Coates L]]
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[[Category: Cooper, J B]]
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[[Category: Cooper JB]]
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[[Category: Erskine, P T]]
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[[Category: Erskine PT]]
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[[Category: Shoolingin-Jordan, P M]]
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[[Category: Shoolingin-Jordan PM]]
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[[Category: Warren, M J]]
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[[Category: Warren MJ]]
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[[Category: Wood, S P]]
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[[Category: Wood SP]]
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[[Category: Youell, J H]]
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[[Category: Youell JH]]
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[[Category: Aldolase]]
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[[Category: Dehydratase]]
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[[Category: Lyase]]
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[[Category: Tetrapyrrole synthesis]]
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[[Category: Tim barrel]]
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Current revision

YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE PUTATIVE CYCLIC REACTION INTERMEDIATE COMPLEX

PDB ID 1ohl

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