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4wsx

From Proteopedia

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The crystal structure of hemagglutinin from A/Jiangxi-Donghu/346/2013 influenza virus

Structural highlights

4wsx is a 24 chain structure with sequence from Influenza A virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.7Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0A0J9X252_9INFA

Publication Abstract from PubMed

During 2013, three new avian influenza A virus subtypes, A(H7N9), A(H6N1) and A(H10N8), resulted in human infections. While the A(H7N9) virus resulted in a significant epidemic in China across 19 provinces and municipalities, both A(H6N1) and A(H10N8) viruses resulted in only a few human infections. This study focuses on the major surface glycoprotein hemagglutinin from both of these novel human viruses. The detailed structural and glycan microarray analyses presented here highlight that both A(H6N1) and A(H10N8) virus hemagglutinins retain a strong avian receptor binding preference, and thus currently pose a low risk for sustained human infections. IMPORTANCE: Human infections with zoonotic influenza virus subtypes continue to be a great public health concern. We report detailed structural analysis and glycan microarray data for recombinant hemagglutinins from A(H6N1) and A(H10N8) viruses, isolated from human infections in 2013, and compare them with hemagglutinins of avian origin. This is the first structural report of an H6 HA, and our results should further the understanding of these viruses, and provide useful information to aid continuous surveillance of these zoonotic influenza viruses.

Structure and receptor binding preferences of recombinant hemagglutinins from avian and human H6 and H10 influenza A virus subtypes.,Yang H, Carney PJ, Chang JC, Villanueva JM, Stevens J J Virol. 2015 Feb 11. pii: JVI.03456-14. PMID:25673707^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Yang H, Carney PJ, Chang JC, Villanueva JM, Stevens J. Structure and receptor binding preferences of recombinant hemagglutinins from avian and human H6 and H10 influenza A virus subtypes. J Virol. 2015 Feb 11. pii: JVI.03456-14. PMID:25673707 doi:http://dx.doi.org/10.1128/JVI.03456-14

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4wsx"

@@ Line 3: / Line 3: @@
 <StructureSection load='4wsx' size='340' side='right'caption='[[4wsx]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4wsx]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WSX FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4wsx]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WSX FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wsr|4wsr]], [[4wss|4wss]], [[4wst|4wst]], [[4wsu|4wsu]], [[4wsv|4wsv]], [[4wsw|4wsw]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsx OCA], [http://pdbe.org/4wsx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wsx RCSB], [http://www.ebi.ac.uk/pdbsum/4wsx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wsx ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsx OCA], [https://pdbe.org/4wsx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wsx RCSB], [https://www.ebi.ac.uk/pdbsum/4wsx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wsx ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A0J9X252_9INFA A0A0J9X252_9INFA]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 21: @@
 ==See Also==
-*[[Hemagglutinin|Hemagglutinin]]
+*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
+[[Category: Influenza A virus]]
 [[Category: Large Structures]]
-[[Category: Carney, P J]]
+[[Category: Carney PJ]]
-[[Category: Chang, J C]]
+[[Category: Chang JC]]
-[[Category: Stevens, J]]
+[[Category: Stevens J]]
-[[Category: Villanueva, J M]]
+[[Category: Villanueva JM]]
-[[Category: Yang, H]]
+[[Category: Yang H]]
-[[Category: H10]]
-[[Category: Hemagglutinin]]
-[[Category: Influenza virus]]
-[[Category: Viral protein]]

4wsx

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Current revision

The crystal structure of hemagglutinin from A/Jiangxi-Donghu/346/2013 influenza virus

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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