4wkr

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<StructureSection load='4wkr' size='340' side='right'caption='[[4wkr]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='4wkr' size='340' side='right'caption='[[4wkr]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wkr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WKR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wkr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WKR FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LARP7, HDCMA18P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wkr OCA], [http://pdbe.org/4wkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wkr RCSB], [http://www.ebi.ac.uk/pdbsum/4wkr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wkr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wkr OCA], [https://pdbe.org/4wkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wkr RCSB], [https://www.ebi.ac.uk/pdbsum/4wkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wkr ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/LARP7_HUMAN LARP7_HUMAN]] Microcephalic primordial dwarfism, Alazami type. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/LARP7_HUMAN LARP7_HUMAN] Microcephalic primordial dwarfism, Alazami type. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LARP7_HUMAN LARP7_HUMAN]] Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.<ref>PMID:18249148</ref> <ref>PMID:18483487</ref>
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[https://www.uniprot.org/uniprot/LARP7_HUMAN LARP7_HUMAN] Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.<ref>PMID:18249148</ref> <ref>PMID:18483487</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Dock-Bregeon, A C]]
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[[Category: Dock-Bregeon A-C]]
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[[Category: Durand, A]]
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[[Category: Durand A]]
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[[Category: Han, X]]
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[[Category: Han X]]
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[[Category: Klaholz, B P]]
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[[Category: Klaholz BP]]
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[[Category: Natchiar, K S]]
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[[Category: Natchiar KS]]
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[[Category: Proux, F]]
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[[Category: Proux F]]
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[[Category: Roblin, P]]
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[[Category: Roblin P]]
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[[Category: Uchikawa, E]]
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[[Category: Uchikawa E]]
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[[Category: Zhang, E]]
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[[Category: Zhang E]]
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[[Category: La motif]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein]]
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[[Category: Rna binding protein]]
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[[Category: Rna recognition motif]]
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[[Category: Rna-binding protein]]
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Current revision

LaRP7 wrapping up the 3' hairpin of 7SK non-coding RNA (302-332)

PDB ID 4wkr

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