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| | <StructureSection load='4v2a' size='340' side='right'caption='[[4v2a]], [[Resolution|resolution]] 2.40Å' scene=''> | | <StructureSection load='4v2a' size='340' side='right'caption='[[4v2a]], [[Resolution|resolution]] 2.40Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4v2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V2A FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4v2a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V2A FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4v2b|4v2b]], [[4v2c|4v2c]], [[4v2d|4v2d]], [[4v2e|4v2e]]</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v2a OCA], [http://pdbe.org/4v2a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v2a RCSB], [http://www.ebi.ac.uk/pdbsum/4v2a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4v2a ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v2a OCA], [https://pdbe.org/4v2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v2a RCSB], [https://www.ebi.ac.uk/pdbsum/4v2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v2a ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/UNC5A_HUMAN UNC5A_HUMAN]] Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. | + | [https://www.uniprot.org/uniprot/UNC5A_HUMAN UNC5A_HUMAN] Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Acker-Palmer, A]] | + | [[Category: Acker-Palmer A]] |
| - | [[Category: Border, E C]] | + | [[Category: Border EC]] |
| - | [[Category: Cop, F]] | + | [[Category: Cop F]] |
| - | [[Category: Haertl, R]] | + | [[Category: Haertl R]] |
| - | [[Category: Harlos, K]] | + | [[Category: Harlos K]] |
| - | [[Category: Jones, E Y]] | + | [[Category: Jones EY]] |
| - | [[Category: Klein, R]] | + | [[Category: Klein R]] |
| - | [[Category: Nagel, D]] | + | [[Category: Nagel D]] |
| - | [[Category: Ruff, T]] | + | [[Category: Ruff T]] |
| - | [[Category: Seiradake, E]] | + | [[Category: Seiradake E]] |
| - | [[Category: Seyit-Bremer, G]] | + | [[Category: Seyit-Bremer G]] |
| - | [[Category: Toro, D del]] | + | [[Category: Del Toro D]] |
| - | [[Category: Apoptosis]]
| + | |
| - | [[Category: Flrt]]
| + | |
| - | [[Category: Netrin receptor]]
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| - | [[Category: Unc5a]]
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| - | [[Category: Uncoordinated-5]]
| + | |
| Structural highlights
Function
UNC5A_HUMAN Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Publication Abstract from PubMed
FLRTs are broadly expressed proteins with the unique property of acting as homophilic cell adhesion molecules and as heterophilic repulsive ligands of Unc5/Netrin receptors. How these functions direct cell behavior and the molecular mechanisms involved remain largely unclear. Here we use X-ray crystallography to reveal the distinct structural bases for FLRT-mediated cell adhesion and repulsion in neurons. We apply this knowledge to elucidate FLRT functions during cortical development. We show that FLRTs regulate both the radial migration of pyramidal neurons, as well as their tangential spread. Mechanistically, radial migration is controlled by repulsive FLRT2-Unc5D interactions, while spatial organization in the tangential axis involves adhesive FLRT-FLRT interactions. Further, we show that the fundamental mechanisms of FLRT adhesion and repulsion are conserved between neurons and vascular endothelial cells. Our results reveal FLRTs as powerful guidance factors with structurally encoded repulsive and adhesive surfaces.
FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development.,Seiradake E, del Toro D, Nagel D, Cop F, Hartl R, Ruff T, Seyit-Bremer G, Harlos K, Border EC, Acker-Palmer A, Jones EY, Klein R Neuron. 2014 Oct 22;84(2):370-85. doi: 10.1016/j.neuron.2014.10.008. Epub 2014, Oct 22. PMID:25374360[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Seiradake E, del Toro D, Nagel D, Cop F, Hartl R, Ruff T, Seyit-Bremer G, Harlos K, Border EC, Acker-Palmer A, Jones EY, Klein R. FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development. Neuron. 2014 Oct 22;84(2):370-85. doi: 10.1016/j.neuron.2014.10.008. Epub 2014, Oct 22. PMID:25374360 doi:http://dx.doi.org/10.1016/j.neuron.2014.10.008
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