Cytochrome b5
From Proteopedia
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<StructureSection load='1b5m' size='350' side='right' caption='Rat heme-containing cytochrome b5 (PDB entry [[1b5m]])' scene='49/490878/Cv/1'> | <StructureSection load='1b5m' size='350' side='right' caption='Rat heme-containing cytochrome b5 (PDB entry [[1b5m]])' scene='49/490878/Cv/1'> | ||
| - | '''Cytochrome b5''' (CB) functions as an electron transport carrier for several membrane-bound oxygenases. <scene name='49/490878/Cv/2'>CB is heme-containing protein</scene>. The microsomal and mitochondrial CB are membrane-bound while bacterial and other animal tissue CB are soluble. | + | '''Cytochrome b5''' (CB) functions as an electron transport carrier for several membrane-bound oxygenases<ref>PMID:12481306</ref>. <scene name='49/490878/Cv/2'>CB is heme-containing protein</scene>. The microsomal and mitochondrial CB are membrane-bound while bacterial and other animal tissue CB are soluble. |
| + | *'''Cytochrome b558''' is a flavoprotein which is a component of NADPH oxidase<ref>PMID:1324665</ref> | ||
| + | *'''Cytochrome b562''' is the the b-type cytochrome from ''E. coli''.<ref>PMID:12559387</ref> | ||
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| + | See also [[Hemeproteins]]. | ||
==3D structures of cytochrome b5== | ==3D structures of cytochrome b5== | ||
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of cytochrome b5== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Cytochrome b5 | ||
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| - | **[[2i96]], [[3ner]] - CB + heme – human - NMR<BR /> | ||
| - | **[[3x32]], [[3x33]], [[3x34]], [[3x35]] – pCB N-terminal + heme - pig<br /> | ||
| - | **[[1cyo]], [[1ehb]], [[3ozz]] – bCB + heme – bovine<br /> | ||
| - | **[[1hko]], [[1nx7]] - bCB + heme - NMR<BR /> | ||
| - | **[[1es1]], [[1i5u]], [[1lqx]], [[1lr6]], [[1m20]], [[1m2i]], [[1m2m]], [[1m59]], [[1u9m]], [[1u9u]], [[4hin]] - bCB (mutant) + heme<br /> | ||
| - | **[[1f03]], [[1f04]], [[1j0q]], [[1sh4]] - bCB (mutant) + heme – NMR<BR /> | ||
| - | **[[1b5m]], [[3mus]] – rCB soluble domain + heme – rat<br /> | ||
| - | **[[1aqa]], [[1aw3]], [[1axx]], [[2axx]], [[1b5a]], [[1b5b]], [[1blv]], [[1bfx]] - rCB soluble domain + heme – NMR<BR /> | ||
| - | **[[1awp]], [[1eue]], [[1icc]], [[1lj0]], [[2i89]] - rCB soluble domain (mutant) + heme<br /> | ||
| - | **[[1ib7]], [[1jex]], [[1mny]], [[5xe4]], [[5xee]] - rCB soluble domain (mutant) + heme - NMR<BR /> | ||
| - | **[[1iet]], [[1ieu]], [[1i87]], [[1i8c]] – rCB – NMR<BR /> | ||
| - | **[[4hil]] – rCB<br /> | ||
| - | **[[1do9]], [[2m33]] - CB soluble domain + heme – rabbit – NMR<BR /> | ||
| - | **[[1x3x]] - CB + heme – Ascaris suum<br /> | ||
| - | **[[2ibj]] - CB + heme – fly<br /> | ||
| - | **[[6nzx]] – CB + heme – ''Hadesarchaea archaeon''<br /> | ||
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| - | *Cytochrome b558 | ||
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| - | **[[1cxy]] – CB + heme – ''Ectothiorhodospira shaposhnikovii'' | ||
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| - | *Cytochrome b562 | ||
| - | **[[6d35]] - fCB + cholesterol - frog<br /> | ||
| - | **[[6d32]] - fCB + cyclopamine<br /> | ||
| - | **[[4er9]] - CB – ''Salmonella enterica''<br /> | ||
| - | **[[256b]], [[5l32]] – EcCB + heme – ''Escherichia coli''<br /> | ||
| - | **[[1qpu]] - EcCB + heme – NMR<BR /> | ||
| - | **[[5yo6]], [[5yo5]], [[5yo4]], [[5yo3]], [[5ym7]] - EcCB (mutant)<br /> | ||
| - | **[[1qq3]] - EcCB (mutant) + heme – NMR<BR /> | ||
| - | **[[1lm3]], [[2bc5]], [[2qla]], [[3c62]], [[3c63]], [[3de8]], [[3de9]], [[3foo]], [[3fop]], [[3hni]], [[3hnj]], [[3hnk]], [[3hnl]], [[3l1m]], [[3iq5]], [[3iq6]], [[3m79]], [[3nmi]], [[3nmj]], [[3nmk]], [[3m15]], [[3m4b]], [[3m4c]], [[6dyl]], [[6dyb]], [[6dhz]] - EcCB (mutant) + heme<br /> | ||
| - | **[[6dyk]] - EcCB (mutant) + heme + Fe + NO<br /> | ||
| - | **[[6dyj]] - EcCB (mutant) + Fe <br /> | ||
| - | **[[6dyi]], [[6dyc]] - EcCB (mutant) + heme + Co<br /> | ||
| - | **[[6dyh]] - EcCB (mutant) + heme + V<br /> | ||
| - | **[[6dyg]], [[6dye]], [[6dy4]] - EcCB (mutant) + heme + Fe<br /> | ||
| - | **[[6dyf]], [[6dyd]] - EcCB (mutant) + heme + Cu<br /> | ||
| - | **[[6dy8]], [[6dy6]] - EcCB (mutant) + heme + Mn<br /> | ||
| - | **[[5l32]] - EcCB + heme + Zn<br /> | ||
| - | **[[6dhy]], [[5xzj]], [[5xzi]], [[5bu7]], [[5awi]], [[5u9e]], [[4u9d]], [[4jeb]], [[4jea]], [[4je9]], [[3tom]], [[3tol]] - EcCB (mutant) + heme + Zn<br /> | ||
| - | **[[1apc]] – EcCB – NMR<BR /> | ||
| - | **[[1m6t]] - EcCB (mutant) | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Porter TD. The roles of cytochrome b5 in cytochrome P450 reactions. J Biochem Mol Toxicol. 2002;16(6):311-6. PMID:12481306 doi:10.1002/jbt.10052
- ↑ Sumimoto H, Sakamoto N, Nozaki M, Sakaki Y, Takeshige K, Minakami S. Cytochrome b558, a component of the phagocyte NADPH oxidase, is a flavoprotein. Biochem Biophys Res Commun. 1992 Aug 14;186(3):1368-75. PMID:1324665 doi:10.1016/s0006-291x(05)81557-8
- ↑ Schenkman JB, Jansson I. The many roles of cytochrome b5. Pharmacol Ther. 2003 Feb;97(2):139-52. PMID:12559387
