Cytochrome P450 hydroxylase
From Proteopedia
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'''Cytochrome P450 hydroxylase''' (CPH) acts in the in-chain hydroxylation of lauric acid which is required for the development of the male organ in higher plants<ref>PMID:24798002</ref>. CPH hydroxylyzes the anti-cholesterol natural product herbosidiene<ref>PMID:25139567</ref>. | '''Cytochrome P450 hydroxylase''' (CPH) acts in the in-chain hydroxylation of lauric acid which is required for the development of the male organ in higher plants<ref>PMID:24798002</ref>. CPH hydroxylyzes the anti-cholesterol natural product herbosidiene<ref>PMID:25139567</ref>. | ||
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| + | See also [[Cytochrome P450]] and [[Hemeproteins]]. | ||
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*<scene name='77/774654/Cv/6'>Lauric acid binding site</scene>. | *<scene name='77/774654/Cv/6'>Lauric acid binding site</scene>. | ||
*<scene name='77/774654/Cv/7'>Heme group binding site</scene>. | *<scene name='77/774654/Cv/7'>Heme group binding site</scene>. | ||
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of cytochrome P450 hydroxylase == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Cytochrome P450 hydroxylase | ||
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| - | **[[2bvj]] – SvCPH PikC – ''Steptomyces venezuelae'' <br /> | ||
| - | **[[3zpi]] – SvCPH PikC (mutant) <br /> | ||
| - | **[[3abb]], [[5cje]] – SaCPH – ''Steptomyces avermitilis'' <br /> | ||
| - | **[[3e5j]], [[3e5l]] – SaCPH (mutant) <br /> | ||
| - | **[[4z5p]], [[4z5q]] – CPH – ''Steptomyces atroolivaceus'' <br /> | ||
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| - | *Cytochrome P450 hydroxylase complex | ||
| - | **[[2c6h]], [[2c7x]], [[2ca0]], [[2cd8]] – SvCPH PikC + macrolactone <br /> | ||
| - | **[[2vz7]], [[2vzm]] – SvCPH PikC (mutant) + macrolactone <br /> | ||
| - | **[[2wi9]] – SvCPH PikC + desosaminyl cyclododecane <br /> | ||
| - | **[[4b7d]] – SvCPH PikC + dimethylamino derivative <br /> | ||
| - | **[[4b7s]], [[4bf4]], [[3zk5]], [[4umz]] – SvCPH PikC (mutant) + dimethylamino derivative <br /> | ||
| - | **[[3aba]] – SaCPH + antifungal <br /> | ||
| - | **[[5cwe]] – SaCPH + lauric acid <br /> | ||
| - | **[[3e5k]] – SaCPH + phenylimidazole <br /> | ||
| - | **[[5vbu]], [[4y8w]] – hCPH + progesterone derivative - human<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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References
- ↑ Yang X, Wu D, Shi J, He Y, Pinot F, Grausem B, Yin C, Zhu L, Chen M, Luo Z, Liang W, Zhang D. Rice CYP703A3, a cytochrome P450 hydroxylase, is essential for development of anther cuticle and pollen exine. J Integr Plant Biol. 2014 Oct;56(10):979-94. doi: 10.1111/jipb.12212. Epub 2014, Jul 15. PMID:24798002 doi:http://dx.doi.org/10.1111/jipb.12212
- ↑ Yu D, Xu F, Shao L, Zhan J. A specific cytochrome P450 hydroxylase in herboxidiene biosynthesis. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4511-4514. doi:, 10.1016/j.bmcl.2014.07.078. Epub 2014 Aug 6. PMID:25139567 doi:http://dx.doi.org/10.1016/j.bmcl.2014.07.078
