5qqw
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5qqw is ON HOLD Authors: Bezerra, G.A., Foster, W., Shrestha L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z136583524== | |
| - | + | <StructureSection load='5qqw' size='340' side='right'caption='[[5qqw]], [[Resolution|resolution]] 1.56Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5qqw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QQW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NU4:2-methyl-N-(pyridin-4-yl)furan-3-carboxamide'>NU4</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> |
| - | [[Category: Foster | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qqw OCA], [https://pdbe.org/5qqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qqw RCSB], [https://www.ebi.ac.uk/pdbsum/5qqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qqw ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bailey H]] | ||
| + | [[Category: Bezerra GA]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Brandao-Neto J]] | ||
| + | [[Category: Brennan PE]] | ||
| + | [[Category: Douangamath A]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Foster W]] | ||
| + | [[Category: Krojer T]] | ||
| + | [[Category: Nicola BB]] | ||
[[Category: Shrestha L]] | [[Category: Shrestha L]] | ||
| - | + | [[Category: Talon R]] | |
| - | + | [[Category: Yue WW]] | |
| - | [[Category: Talon | + | [[Category: Von Delft F]] |
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| - | [[Category: Yue | + | |
| - | [[Category: Von Delft | + | |
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Current revision
PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z136583524
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bailey H | Bezerra GA | Bountra C | Brandao-Neto J | Brennan PE | Douangamath A | Edwards A | Foster W | Krojer T | Nicola BB | Shrestha L | Talon R | Yue WW | Von Delft F
