6rqs
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==RW16 peptide== | |
| + | <StructureSection load='6rqs' size='340' side='right'caption='[[6rqs]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6rqs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RQS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=KFB:5-Aminovaleric+Acid'>KFB</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rqs OCA], [https://pdbe.org/6rqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rqs RCSB], [https://www.ebi.ac.uk/pdbsum/6rqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rqs ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cell-penetrating peptides (CPPs) are short peptides that can translocate and transport cargoes into the intracellular milieu by crossing biological membranes. The mode of interaction and internalization of cell-penetrating peptides has long been controversial. While their interaction with anionic membranes is quite well understood, the insertion and behavior of CPPs in zwitterionic membranes, a major lipid component of eukaryotic cell membranes, is poorly studied. Herein, we investigated the membrane insertion of RW16 into zwitterionic membranes, a versatile CPP that also presents antibacterial and antitumor activities. Using complementary approaches, including NMR spectroscopy, fluorescence spectroscopy, circular dichroism, and molecular dynamic simulations, we determined the high-resolution structure of RW16 and measured its membrane insertion and orientation properties into zwitterionic membranes. Altogether, these results contribute to explaining the versatile properties of this peptide toward zwitterionic lipids. | ||
| - | + | Biophysical Insight on the Membrane Insertion of an Arginine-Rich Cell-Penetrating Peptide.,Jobin ML, Vamparys L, Deniau R, Grelard A, Mackereth CD, Fuchs PFJ, Alves ID Int J Mol Sci. 2019 Sep 9;20(18). pii: ijms20184441. doi: 10.3390/ijms20184441. PMID:31505894<ref>PMID:31505894</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Alves | + | <div class="pdbe-citations 6rqs" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Alves I]] | ||
| + | [[Category: Grelard A]] | ||
| + | [[Category: Jobin M-L]] | ||
| + | [[Category: Mackereth CD]] | ||
Current revision
RW16 peptide
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