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5zxa

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==Crystal structure of a protein mutant from Mycobacterium==
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==Crystal structure of fibronectin-binding protein Apa mutant from Mycobacterium tuberculosis==
<StructureSection load='5zxa' size='340' side='right'caption='[[5zxa]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
<StructureSection load='5zxa' size='340' side='right'caption='[[5zxa]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zxa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZXA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zxa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZXA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxa OCA], [http://pdbe.org/5zxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zxa RCSB], [http://www.ebi.ac.uk/pdbsum/5zxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxa ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxa OCA], [https://pdbe.org/5zxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zxa RCSB], [https://www.ebi.ac.uk/pdbsum/5zxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxa ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/APA_MYCTU APA_MYCTU]] A potent antigen in animals immunized with live bacteria, it induces a strong delayed-type hypersensitivity (DTH) in immunized animals (PubMed:10531201). Elicits a mostly Th1 type of T-cell response in healthy humans; induces IFN-gamma production from CD4(+) and CD8(+) cells (PubMed:12654810). Functions as an adhesin, binds to mouse macrophages via mannose residues (PubMed:10531201, PubMed:25359607). Might interact via host CD209 (PubMed:16092920).<ref>PMID:10531201</ref> <ref>PMID:12654810</ref> <ref>PMID:16092920</ref> <ref>PMID:25359607</ref>
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[https://www.uniprot.org/uniprot/APA_MYCTU APA_MYCTU] A potent antigen in animals immunized with live bacteria, it induces a strong delayed-type hypersensitivity (DTH) in immunized animals (PubMed:10531201). Elicits a mostly Th1 type of T-cell response in healthy humans; induces IFN-gamma production from CD4(+) and CD8(+) cells (PubMed:12654810). Functions as an adhesin, binds to mouse macrophages via mannose residues (PubMed:10531201, PubMed:25359607). Might interact via host CD209 (PubMed:16092920).<ref>PMID:10531201</ref> <ref>PMID:12654810</ref> <ref>PMID:16092920</ref> <ref>PMID:25359607</ref>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, C C]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Gao, J]]
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[[Category: Chen CC]]
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[[Category: Guo, R T]]
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[[Category: Gao J]]
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[[Category: Liu, W D]]
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[[Category: Guo RT]]
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[[Category: Cyclolavandulyl diphosphate synthase]]
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[[Category: Liu WD]]
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[[Category: Inhibitor]]
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[[Category: Protein binding]]
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[[Category: Substrate binding]]
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Current revision

Crystal structure of fibronectin-binding protein Apa mutant from Mycobacterium tuberculosis

PDB ID 5zxa

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