6mjw
From Proteopedia
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<StructureSection load='6mjw' size='340' side='right'caption='[[6mjw]], [[Resolution|resolution]] 2.41Å' scene=''> | <StructureSection load='6mjw' size='340' side='right'caption='[[6mjw]], [[Resolution|resolution]] 2.41Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6mjw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJW OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6mjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MJW FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JUJ:1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one'>JUJ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.405Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JUJ:1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one'>JUJ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjw OCA], [https://pdbe.org/6mjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mjw RCSB], [https://www.ebi.ac.uk/pdbsum/6mjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjw ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref> |
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| + | ==See Also== | ||
| + | *[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Adura | + | [[Category: Adura C]] |
| - | [[Category: Aida | + | [[Category: Aida J]] |
| - | [[Category: Asano | + | [[Category: Asano Y]] |
| - | [[Category: Gao | + | [[Category: Gao P]] |
| - | [[Category: Glickman | + | [[Category: Glickman JF]] |
| - | [[Category: Gogakos | + | [[Category: Gogakos T]] |
| - | [[Category: Hashizume | + | [[Category: Hashizume S]] |
| - | [[Category: Imaeda | + | [[Category: Imaeda T]] |
| - | [[Category: Jennings | + | [[Category: Jennings AJ]] |
| - | [[Category: Kamei | + | [[Category: Kamei T]] |
| - | [[Category: Kuroita | + | [[Category: Kuroita T]] |
| - | [[Category: Kuryavyi | + | [[Category: Kuryavyi V]] |
| - | [[Category: Lama | + | [[Category: Lama L]] |
| - | [[Category: Meinke | + | [[Category: Meinke P]] |
| - | [[Category: Michinom | + | [[Category: Michinom M]] |
| - | [[Category: Miller | + | [[Category: Miller M]] |
| - | [[Category: Okamoto | + | [[Category: Okamoto R]] |
| - | [[Category: Patel | + | [[Category: Patel DJ]] |
| - | [[Category: Ramos-Espiritu | + | [[Category: Ramos-Espiritu L]] |
| - | [[Category: Stamford | + | [[Category: Stamford A]] |
| - | [[Category: Steinberg | + | [[Category: Steinberg JI]] |
| - | [[Category: Tomita | + | [[Category: Tomita D]] |
| - | [[Category: Tuschl | + | [[Category: Tuschl T]] |
| - | [[Category: Xie | + | [[Category: Xie W]] |
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Current revision
human cGAS catalytic domain bound with the inhibitor G150
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Categories: Homo sapiens | Large Structures | Adura C | Aida J | Asano Y | Gao P | Glickman JF | Gogakos T | Hashizume S | Imaeda T | Jennings AJ | Kamei T | Kuroita T | Kuryavyi V | Lama L | Meinke P | Michinom M | Miller M | Okamoto R | Patel DJ | Ramos-Espiritu L | Stamford A | Steinberg JI | Tomita D | Tuschl T | Xie W
