6mjx

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Current revision

human cGAS catalytic domain bound with cGAMP

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Retrieved from "http://52.214.119.220/wiki/index.php/6mjx"

@@ Line 3: / Line 3: @@
 <StructureSection load='6mjx' size='340' side='right'caption='[[6mjx]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6mjx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJX FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6mjx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MJX FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjx OCA], [http://pdbe.org/6mjx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mjx RCSB], [http://www.ebi.ac.uk/pdbsum/6mjx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjx ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjx OCA], [https://pdbe.org/6mjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mjx RCSB], [https://www.ebi.ac.uk/pdbsum/6mjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjx ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
+[https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
+==See Also==
+*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Cyclic GMP-AMP synthase]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Adura, C]]
+[[Category: Adura C]]
-[[Category: Aida, J]]
+[[Category: Aida J]]
-[[Category: Asano, Y]]
+[[Category: Asano Y]]
-[[Category: Gao, P]]
+[[Category: Gao P]]
-[[Category: Glickman, J F]]
+[[Category: Glickman JF]]
-[[Category: Gogakos, T]]
+[[Category: Gogakos T]]
-[[Category: Hashizume, S]]
+[[Category: Hashizume S]]
-[[Category: Imaeda, T]]
+[[Category: Imaeda T]]
-[[Category: Jennings, A J]]
+[[Category: Jennings AJ]]
-[[Category: Kamei, T]]
+[[Category: Kamei T]]
-[[Category: Kuroita, T]]
+[[Category: Kuroita T]]
-[[Category: Kuryavyi, V]]
+[[Category: Kuryavyi V]]
-[[Category: Lama, L]]
+[[Category: Lama L]]
-[[Category: Meinke, P]]
+[[Category: Meinke P]]
-[[Category: Michinom, M]]
+[[Category: Michinom M]]
-[[Category: Miller, M]]
+[[Category: Miller M]]
-[[Category: Okamoto, R]]
+[[Category: Okamoto R]]
-[[Category: Patel, D J]]
+[[Category: Patel DJ]]
-[[Category: Ramos-Espiritu, L]]
+[[Category: Ramos-Espiritu L]]
-[[Category: Stamford, A]]
+[[Category: Stamford A]]
-[[Category: Steinberg, J I]]
+[[Category: Steinberg JI]]
-[[Category: Tomita, D]]
+[[Category: Tomita D]]
-[[Category: Tuschl, T]]
+[[Category: Tuschl T]]
-[[Category: Xie, W]]
+[[Category: Xie W]]
-[[Category: Dna sensor]]
-[[Category: Human cga]]
-[[Category: Immune system]]
-[[Category: Transferase-transferase inhibitor complex]]

6mjx

From Proteopedia

Current revision

human cGAS catalytic domain bound with cGAMP

Structural highlights

Function

See Also

References

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