4xo2

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<StructureSection load='4xo2' size='340' side='right'caption='[[4xo2]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4xo2' size='340' side='right'caption='[[4xo2]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4xo2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XO2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4xo2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XO2 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xo1|4xo1]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.952&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gnsA, yccL, b4517, JW0976 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xo2 OCA], [https://pdbe.org/4xo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xo2 RCSB], [https://www.ebi.ac.uk/pdbsum/4xo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xo2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xo2 OCA], [http://pdbe.org/4xo2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xo2 RCSB], [http://www.ebi.ac.uk/pdbsum/4xo2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xo2 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GNSA_ECOLI GNSA_ECOLI]] Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation.<ref>PMID:11544213</ref>
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[https://www.uniprot.org/uniprot/GNSA_ECOLI GNSA_ECOLI] Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation.<ref>PMID:11544213</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Escherichia Coli GnsA is a regulator of phosphatidylethanolamine synthesis and functions as a suppressor of both a secG null mutation and fabA6 mutations. GnsA may also be a toxin with the cognate antitoxin YmcE. Here we report the crystal structure of GnsA to 1.8 A. GnsA forms a V shaped hairpin structure that is tightly associated into a homodimer. Our comprehensive structural study suggests that GnsA is structurally similar to an outer membrane protein, suggesting a function of protein binding.
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Crystal structure of GnsA from Escherichia coli.,Wei Y, Zhan L, Gao Z, Prive GG, Dong Y Biochem Biophys Res Commun. 2015 Jun 19;462(1):1-7. doi:, 10.1016/j.bbrc.2015.03.133. Epub 2015 Apr 1. PMID:25839658<ref>PMID:25839658</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4xo2" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Dong, Y H]]
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[[Category: Dong YH]]
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[[Category: Gao, Z Q]]
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[[Category: Gao ZQ]]
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[[Category: Wei, Y]]
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[[Category: Wei Y]]
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[[Category: Zhan, L H]]
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[[Category: Zhan LH]]
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[[Category: Protein binding]]
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[[Category: Suppressor]]
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Current revision

crystal structure of GnsA from E.coli

PDB ID 4xo2

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OCA

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