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1byr

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CRYSTAL STRUCTURE OF A PHOSPHOLIPASE D FAMILY MEMBER, NUC FROM SALMONELLA TYPHIMURIUM

Structural highlights

1byr is a 1 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q46707_ECOLX

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The first crystal structure of a phospholipase D (PLD) family member has been determined at 2.0 A resolution. The PLD superfamily is defined by a common sequence motif, HxK(x)4D(x)6GSxN, and includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. The crystal structure suggests that residues from two sequence motifs form a single active site. A histidine residue from one motif acts as a nucleophile in the catalytic mechanism, forming a phosphoenzyme intermediate, whereas a histidine residue from the other motif appears to function as a general acid in the cleavage of the phosphodiester bond. The structure suggests that the conserved lysine residues are involved in phosphate binding. Large-scale genomic sequencing revealed that there are many PLD family members. Our results suggest that all of these proteins may possess a common structure and catalytic mechanism.

Crystal structure of a phospholipase D family member.,Stuckey JA, Dixon JE Nat Struct Biol. 1999 Mar;6(3):278-84. PMID:10074947^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Stuckey JA, Dixon JE. Crystal structure of a phospholipase D family member. Nat Struct Biol. 1999 Mar;6(3):278-84. PMID:10074947 doi:10.1038/6716

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1byr"

Categories: Large Structures | Salmonella enterica subsp. enterica serovar Typhimurium | Dixon JE | Stuckey JA

@@ Line 3: / Line 3: @@
 <StructureSection load='1byr' size='340' side='right'caption='[[1byr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1byr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BYR FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1byr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BYR FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bys|1bys]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1byr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byr OCA], [http://pdbe.org/1byr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1byr RCSB], [http://www.ebi.ac.uk/pdbsum/1byr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1byr ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1byr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byr OCA], [https://pdbe.org/1byr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1byr RCSB], [https://www.ebi.ac.uk/pdbsum/1byr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1byr ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q46707_ECOLX Q46707_ECOLX]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 31: / Line 33: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Dixon, J E]]
+[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-[[Category: Stuckey, J A]]
+[[Category: Dixon JE]]
-[[Category: Endonuclease]]
+[[Category: Stuckey JA]]
-[[Category: Phosphodiesterase]]

1byr

From Proteopedia

Current revision

CRYSTAL STRUCTURE OF A PHOSPHOLIPASE D FAMILY MEMBER, NUC FROM SALMONELLA TYPHIMURIUM

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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