4xc5

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<StructureSection load='4xc5' size='340' side='right'caption='[[4xc5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4xc5' size='340' side='right'caption='[[4xc5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4xc5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mrv-1 Mrv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XC5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4xc5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_1_Lang Mammalian orthoreovirus 1 Lang]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XC5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3s6x|3s6x]], [[1kke|1kke]], [[4gu3|4gu3]], [[4odb|4odb]], [[3eoy|3eoy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10884 MRV-1])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc5 OCA], [https://pdbe.org/4xc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xc5 RCSB], [https://www.ebi.ac.uk/pdbsum/4xc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc5 OCA], [http://pdbe.org/4xc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xc5 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xc5 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL]] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity).
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[https://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4xc5" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4xc5" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Mrv-1]]
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[[Category: Mammalian orthoreovirus 1 Lang]]
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[[Category: Reiss, K]]
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[[Category: Reiss K]]
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[[Category: Stehle, T]]
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[[Category: Stehle T]]
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[[Category: 3-sialyllactose]]
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[[Category: Beta-barrel]]
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[[Category: Beta-spiral repeat]]
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[[Category: Gm2 glycan alpha-2]]
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[[Category: Greek key motif]]
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[[Category: Junctional adhesion molecule some]]
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[[Category: Triple beta-spiral]]
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[[Category: Viral attachment protein]]
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[[Category: Viral capsid]]
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[[Category: Viral protein]]
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Current revision

CRYSTAL STRUCTURE OF THE T1L REOVIRUS ATTACHMENT PROTEIN SIGMA1

PDB ID 4xc5

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