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Integrin
From Proteopedia
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<scene name='51/516472/Cv/4'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres. | <scene name='51/516472/Cv/4'>Mg/Cl coordination site</scene>. Water molecules shown as red spheres. | ||
| - | </StructureSection> | ||
==3D structures of integrin== | ==3D structures of integrin== | ||
| + | [[Integrin 3D structures]] | ||
| + | </StructureSection> | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *IG CR3 | ||
| - | |||
| - | **[[1ido]] – hIG I domain + Mg – human<br /> | ||
| - | **[[1jlm]] - hIG I domain + Mn<br /> | ||
| - | |||
| - | *IG CD11a or IG α-L | ||
| - | |||
| - | **[[1lfa]] - hIG I domain + Mn<br /> | ||
| - | **[[1zon]] - hIG I domain<br /> | ||
| - | **[[1zoo]], [[1zop]], [[3f74]] - hIG I domain + Mg<br /> | ||
| - | **[[1mq9]] - hIG I domain (mutant) + Mn<br /> | ||
| - | **[[1mjn]] - hIG I domain (mutant) + Mg<br /> | ||
| - | **[[1mqa]] - hIG I domain (mutant) <br /> | ||
| - | **[[2k8o]] – hIG cytoplasmic domain (mutant) – NMR<BR /> | ||
| - | |||
| - | *''IG CD11a complexes'' | ||
| - | |||
| - | **[[1cqp]] - hIG I domain + lovastatin + Mg<br /> | ||
| - | **[[1mq8]], [[3bn3]], [[3tcx]] - hIG I domain (mutant) + intracellular adhesion molecule + Mg<br /> | ||
| - | **[[1t0p]] - hIG I domain + intracellular adhesion molecule-3 + Mg<br /> | ||
| - | **[[1rd4]], [[2ica]], [[3bqm]], [[3bqn]], [[3e2m]] - hIG I domain + inhibitor<br /> | ||
| - | **[[2o7n]], [[3m6f]] - hIG I domain + antagonist<br /> | ||
| - | **[[1xdd]], [[1xdg]], [[1xuo]] - hIG I domain + inhibitor + Mg<br /> | ||
| - | **[[4ixd]] - hIG I domain + activator + Mg<br /> | ||
| - | **[[3f78]] - hIG I domain + anesthetic + Mg<br /> | ||
| - | **[[3eoa]], [[3eob]] - hIG I domain + antibody<br /> | ||
| - | **[[3hi6]] - hIG I domain (mutant) + antibody + Mn<br /> | ||
| - | |||
| - | *IG CD11b | ||
| - | |||
| - | **[[1bho]] - hIG I domain + Mg<br /> | ||
| - | **[[1bhq]] - hIG I domain + Cd<br /> | ||
| - | **[[1m1u]] - hIG I domain (mutant) + Ca<br /> | ||
| - | **[[1n9z]] - hIG I domain (mutant) + Mg<br /> | ||
| - | **[[1idn]], [[1na5]] - hIG I domain<br /> | ||
| - | **[[1mf7]] - hIG I domain (mutant) | ||
| - | |||
| - | *IG CD11c | ||
| - | |||
| - | **[[1n3y]] - hIG I domain (mutant) | ||
| - | |||
| - | *IG α-1 (CD49a) | ||
| - | |||
| - | **[[1ck4]] - rIG I domain – rat<br /> | ||
| - | **[[4a0q]] - hIG I domain (mutant) + Mg<br /> | ||
| - | **[[2l8s]] - hIG transmembrane domain – NMR<BR /> | ||
| - | **[[5hgj]] - hIG VWFA domain<br /> | ||
| - | **[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br /> | ||
| - | **[[2b2x]] - rIG I domain (mutant) + antibody + Mg<br /> | ||
| - | **[[2m32]] - hIG I domain + collagen peptide<br /> | ||
| - | |||
| - | *IG α-2 (CD49b) | ||
| - | |||
| - | **[[4bj3]], [[5e6x]], [[5e6v]] - hIG I domain<br /> | ||
| - | **[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br /> | ||
| - | **[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br /> | ||
| - | **[[5thp]] - hIG residues 170-366 + rhodocetin <br /> | ||
| - | |||
| - | *IG α-2b | ||
| - | |||
| - | **[[2k1a]] - hIG transmembrane domain – NMR<BR /> | ||
| - | |||
| - | *IG α-1 β-1 (CD49a-CD49b) | ||
| - | |||
| - | **[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br /> | ||
| - | **[[1pt6]] - hIG I domain + Mg<br /> | ||
| - | |||
| - | *IG α-2 (CD49b) β | ||
| - | |||
| - | **[[5hj2]] - hIG I domain<br /> | ||
| - | **[[1aox]] - hIG I domain (mutant) + Mg<br /> | ||
| - | **[[2k1a]] - hIG transmembrane domain – NMR<br /> | ||
| - | |||
| - | *IG α-2b β-3 (CD61) | ||
| - | |||
| - | **[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR /> | ||
| - | **[[1m8o]] - hIG cytoplasmic domain – NMR<BR /> | ||
| - | **[[4cak]] – hIG – Cryo-EM<br /> | ||
| - | **[[2k9j]], [[2knc]] - hIG transmembrane domain – NMR<BR /> | ||
| - | **[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br /> | ||
| - | **[[3fc3]] – hIG (mutant) + Mg<br /> | ||
| - | **[[2vc2]], [[2vdk]], [[2vdl]], [[3nid]], [[3nif]], [[3nig]], [[3zdx]], [[3zdy]], [[3zdz]], [[3ze0]], [[3ze1]], [[3ze2]], [[5hdb]] – hIG headpiece + antibody + Mg<br /> | ||
| - | **[[4z7q]], [[4z7o]], [[4z7n]] – hIG headpiece + antibody + Mg + tetrapeptide<br /> | ||
| - | **[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br /> | ||
| - | **[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br /> | ||
| - | |||
| - | *IG α-4 | ||
| - | |||
| - | **[[4irz]] - hIG + antibody <br /> | ||
| - | |||
| - | *IG α-4 (CD49d) β-7 | ||
| - | |||
| - | **[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br /> | ||
| - | **[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br /> | ||
| - | |||
| - | *IG α-5 (CD49e) β-1 (CD29) | ||
| - | |||
| - | **[[4wjk]] - hIG headpiece (mutant) + Mg<br /> | ||
| - | **[[4wk0]], [[4wk2]], [[4wk4]] - hIG headpiece (mutant) + peptide + Mg<br /> | ||
| - | **[[3vi3]] - hIG headpiece + antibody + Mg<br /> | ||
| - | **[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br /> | ||
| - | |||
| - | *IG α-5 (CD49e) β-3 (CD61) ectodomain | ||
| - | |||
| - | **[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br /> | ||
| - | **[[4mmx]], [[4mmy]], [[4mmz]] - hIG + Mn + fibronectin domain 10<br /> | ||
| - | **[[4o02]], [[6avu]], [[6avr]], [[6avq]] - hIG + antibody<br /> | ||
| - | **[[1jv2]] - hIG + platelet membrane glycoprotein IIIA + Ca<br /> | ||
| - | **[[1l5g]] - hIG + tripeptide + Mn<br /> | ||
| - | |||
| - | *IG α-5 β-6 | ||
| - | |||
| - | **[[4um8]] – hIG headpiece (mutant) + Ni<br /> | ||
| - | **[[5ffg]] – hIG headpiece + Ca<br /> | ||
| - | **[[4um9]] – hIG headpiece (mutant) + Mg + transforming growth factor β 3<br /> | ||
| - | **[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br /> | ||
| - | **[[5ffo]] – hIG headpiece + TGF-beta-1<br /> | ||
| - | |||
| - | *IG α-L | ||
| - | |||
| - | **[[4ixd]] – hIG I domain<br /> | ||
| - | **[[5e6s]], [[5e6r]] – hIG AI, headpiece,pocket domains + Mg<br /> | ||
| - | **[[2m3e]] – hIG transmembrane domain - NMR<br /> | ||
| - | |||
| - | *IG α-L β-2 | ||
| - | |||
| - | **[[5e6u]] – hIG headpiece (mutant) + Ni<br /> | ||
| - | |||
| - | *IG α-M | ||
| - | |||
| - | **[[3q3g]], [[3qa3]] – hIG + antibody<br /> | ||
| - | **[[4m76]] – hIG + complement C3<br /> | ||
| - | **[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR /> | ||
| - | **[[4xw2]] – hIG + simvastatin<br /> | ||
| - | |||
| - | *IG α-X | ||
| - | |||
| - | **[[2luv]] – hIG cytoplasmic domain – NMR<BR /> | ||
| - | |||
| - | *IG α-X β-2 (CD18) | ||
| - | |||
| - | **[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br /> | ||
| - | **[[4neh]], [[4nen]] – hIG (mutant) + Mg<br /> | ||
| - | |||
| - | *IG β-1D | ||
| - | |||
| - | **[[3g9w]] – hIG cytoplasmic tail + talin 2 F2-F3 domain<br /> | ||
| - | |||
| - | *IG β-2 (CD18) | ||
| - | |||
| - | **[[2p26]], [[2p28]], [[5e6w]] – hIG phe2 + phe3 domains<br /> | ||
| - | **[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br /> | ||
| - | |||
| - | *IG β-3 (CD61) | ||
| - | |||
| - | **[[1s4x]], [[2kv9]], [[2ljd]], [[2lje]], [[2ljf]] – hIG cytoplasmic domain – NMR<BR /> | ||
| - | **[[2rmz]], [[2rn0]] – hIG transmembrane domain – NMR<BR /> | ||
| - | **[[2l91]] - hIG transmembrane domain (mutant) – NMR<BR /> | ||
| - | **[[2l1c]] – hIG cytoplasmic tail + SHC<br /> | ||
| - | **[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br /> | ||
| - | |||
| - | *IG β-4 (CD104) | ||
| - | |||
| - | **[[2f7q]], [[3f7r]], [[1qg3]], [[3f7q]], [[4wtw]], [[4wtx]] - hIG fibronectin type III domain<br /> | ||
| - | **[[2yrz]] – hIG fibronectin type III domain – NMR<BR /> | ||
| - | **[[3f7p]], [[4q58]] - hIG fibronectin type III domain + plectin-1 <br /> | ||
| - | **[[3fq4]], [[3fso]], [[3h6a]] – hIG Calx-β domain | ||
| - | |||
| - | *IG β-7 | ||
| - | |||
| - | **[[2brq]], [[2jf1]] – hIG cytoplasmic tail + filamin rod domain<br /> | ||
| - | |||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914
- ↑ Hillis GS, MacLeod AM. Integrins and disease. Clin Sci (Lond). 1996 Dec;91(6):639-50. PMID:8976799
- ↑ Larjava H, Koivisto L, Heino J, Hakkinen L. Integrins in periodontal disease. Exp Cell Res. 2014 Jul 15;325(2):104-10. doi: 10.1016/j.yexcr.2014.03.010. Epub, 2014 Mar 22. PMID:24662197 doi:http://dx.doi.org/10.1016/j.yexcr.2014.03.010
- ↑ Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914
