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6jqo
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of PaaZ, a bifunctional enzyme in complex with NADP+ and CCoA== | |
| - | + | <SX load='6jqo' size='340' side='right' viewer='molstar' caption='[[6jqo]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6jqo]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JQO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COO:CROTONYL+COENZYME+A'>COO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jqo OCA], [https://pdbe.org/6jqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jqo RCSB], [https://www.ebi.ac.uk/pdbsum/6jqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jqo ProSAT]</span></td></tr> |
| - | [[Category: Cannone | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PAAZ_ECOLI PAAZ_ECOLI] Catalyzes the hydrolytic ring cleavage of 2-oxepin-2(3H)-ylideneacetyl-CoA (oxepin-CoA) via the open-chain aldehyde intermediate to yield 3-oxo-5,6-dehydrosuberyl-CoA. The enzyme consists of a C-terminal (R)-specific enoyl-CoA hydratase domain (formerly MaoC) that cleaves the ring and produces the highly reactive 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde and an N-terminal NADP-dependent aldehyde dehydrogenase domain that oxidizes the aldehyde to 3-oxo-5,6-dehydrosuberyl-CoA. Can also use crotonyl-CoA as substrate.<ref>PMID:20660314</ref> <ref>PMID:21296885</ref> <ref>PMID:9748275</ref> |
| - | [[Category: Sathyanarayanan | + | == References == |
| - | [[Category: Sowdhamini | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </SX> | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cannone G]] | ||
| + | [[Category: Gakher L]] | ||
| + | [[Category: Katagihallimath N]] | ||
| + | [[Category: Sathyanarayanan N]] | ||
| + | [[Category: Sowdhamini R]] | ||
| + | [[Category: Vinothkumar KR]] | ||
Current revision
Structure of PaaZ, a bifunctional enzyme in complex with NADP+ and CCoA
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