6k51
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6k51 is ON HOLD Authors: Wang, J.H., Mao, R.Y., Liu, X.H. Description: Solution structure of plectasin derivative MP1102 [[Category: Unreleased Str...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of plectasin derivative MP1102== | |
| - | + | <StructureSection load='6k51' size='340' side='right'caption='[[6k51]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6k51]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudoplectania_nigrella Pseudoplectania nigrella]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K51 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k51 OCA], [https://pdbe.org/6k51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k51 RCSB], [https://www.ebi.ac.uk/pdbsum/6k51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k51 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Liu | + | == Function == |
| - | [[Category: Mao | + | [https://www.uniprot.org/uniprot/DEFPL_PSENR DEFPL_PSENR] Antimicrobial peptide that potently acts against several species of Gram-positive bacteria (PubMed:16222292, PubMed:19472324). It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis (PubMed:20508130). It does not disrupt cell membranes (PubMed:20508130). Is especially active against numerous clinical isolates of S.pneumoniae, including all 90 different serotypes and isolates resistant to clinically used antibiotics (PubMed:16222292). In vitro, shows considerable selectivity for bacteria over mammalian cells (PubMed:16222292). The peptide synthesized in D-amino acids does not show antibacterial activity (PubMed:19472324). In vitro, acts on voltage-gated potassium channels by moderately inhibiting mammalian Kv1.3/KCNA3 (IC(50)=2.8 uM), and moderately inhibiting others potassium channels (PubMed:25568977).<ref>PMID:16222292</ref> <ref>PMID:25568977</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudoplectania nigrella]] | ||
| + | [[Category: Liu XH]] | ||
| + | [[Category: Mao RY]] | ||
| + | [[Category: Wang JH]] | ||
Current revision
Solution structure of plectasin derivative MP1102
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